Search

Displaying results 1021 - 1030 of 1993 in total
  1. Target

    Neuronal Acetylcholine (nACh) Receptor Subunits

    go.drugbank.com/bio_entities/BE0009927
    TargetHumans

    Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4 (PubMed:11118490, PubMed:16835356). … CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:31488329).

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-10, Neuronal acetylcholine receptor subunit alpha-2Synonyms: Nicotinic acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-2
  2. Target

    Free fatty acid receptor 3

    go.drugbank.com/bio_entities/BE0010132
    TargetHumans

    That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. … G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis

    Polypeptides: Free fatty acid receptor 3Synonyms: G protein-coupled receptor 41
  3. Target

    Vascular endothelial growth factor receptor

    go.drugbank.com/bio_entities/BE0010227
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. … Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival

    Polypeptides: Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2Synonyms: Kinase insert domain receptor, Tyrosine-protein kinase receptor FLT
  4. Target

    Cytokine receptor-like factor 2

    go.drugbank.com/bio_entities/BE0010586
    TargetHumans

    Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5.

    Polypeptides: Cytokine receptor-like factor 2Synonyms: TSLP receptor, Cytokine receptor-like 2
  5. Target

    Interleukin-31 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0011013
    TargetHumans

    In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15194700, PubMed:15627637). … Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (PubMed:15184896, PubMed:15194700, PubMed:15627637).

    Polypeptides: Interleukin-31 receptor subunit alphaSynonyms: IL-31 receptor A, Gp130-like receptor
  6. Target

    Vasoactive intestinal polypeptide receptor 1

    go.drugbank.com/bio_entities/BE0013137
    TargetHumans

    G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed

    Polypeptides: Vasoactive intestinal polypeptide receptor 1Synonyms: VPAC1 receptor, PACAP type II receptor
  7. Target

    GDNF family receptor alpha-1

    go.drugbank.com/bio_entities/BE0013583
    TargetHumans

    GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977)

    Polypeptides: GDNF family receptor alpha-1Synonyms: GDNF receptor alpha-1, TGF-beta-related neurotrophic factor receptor 1
  8. Target

    Corticotropin-releasing hormone receptor 2

    go.drugbank.com/bio_entities/BE0014244
    TargetHumans

    G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579

    Polypeptides: Corticotropin-releasing hormone receptor 2Synonyms: Corticotropin-releasing factor receptor 2
  9. Target

    Interleukin-10 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0014391
    TargetHumans

    Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

    Polypeptides: Interleukin-10 receptor subunit alphaSynonyms: IL-10 receptor subunit alpha, Interleukin-10 receptor subunit 1
  10. Target

    G protein-coupled receptor 68

    go.drugbank.com/bio_entities/BE0014724
    TargetHumans

    The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). … Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed

    Polypeptides: G protein-coupled receptor 68Synonyms: G protein-coupled receptor 12A, Ovarian cancer G protein-coupled receptor 1