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Displaying results 1021 - 1030 of 1809 in total
  1. Drug

    Guvacine

    go.drugbank.com/drugs/DB08848
    Experimental

    Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication.

  2. Target

    Nuclear receptor subfamily 1 group I member 2

    go.drugbank.com/bio_entities/BE0000956
    TargetHumans

    Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation.

    Polypeptides: Nuclear receptor subfamily 1 group I member 2Synonyms: Pregnane X receptor, Orphan nuclear receptor PAR1
  3. Target

    Gamma-aminobutyric acid type B receptor subunit 2

    go.drugbank.com/bio_entities/BE0002340
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase ( … Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 2, G protein-coupled receptor 51
  4. Target

    Nuclear receptor subfamily 1 group I member 3

    go.drugbank.com/bio_entities/BE0003848
    TargetHumans

    Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes.

    Polypeptides: Nuclear receptor subfamily 1 group I member 3Synonyms: Orphan nuclear receptor MB67, Constitutive androstane receptor
  5. Target

    Peroxisome proliferator-activated receptor gamma coactivator 1-beta

    go.drugbank.com/bio_entities/BE0009812
    TargetHumans

    Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids.

    Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-betaSynonyms: PGC-1-related estrogen receptor alpha coactivator
  6. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 2

    go.drugbank.com/bio_entities/BE0010561
    TargetHumans

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 2Synonyms: Leukocyte immunoglobulin-like receptor 2, Monocyte/macrophage immunoglobulin-like receptor 10
  7. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 1

    go.drugbank.com/bio_entities/BE0010562
    TargetHumans

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). … Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 1Synonyms: Leukocyte immunoglobulin-like receptor 1, Monocyte/macrophage immunoglobulin-like receptor 7
  8. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 4

    go.drugbank.com/bio_entities/BE0017129
    TargetHumans

    This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). … Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213).

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 4Synonyms: Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor 5
  9. Target

    Mas-related G protein-coupled receptor member X2

    go.drugbank.com/bio_entities/BE0018408
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109

    Polypeptides: Mas-related G protein-coupled receptor member X2Function: C-C chemokine receptor activity
  10. Drug

    Malacidin A

    go.drugbank.com/drugs/DB14051
    Experimental

    Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. … While structurally similar to other macrocycle drugs like [DB00080] and [DB06087], Malacidin A appears to act via its own distinct mechanism.