Search
Norethisterone Action Pathway
smpdb.ca/view/SMP0126536Drug actionNorethisterone, also known as norethindrone, is a synthetic progestational hormone used for contraception, prevention of endometrial hyperplasia (hormone replacement therapy), and in the treatment of other hormone-related illnesses. This...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Segesterone acetate Action Pathway
smpdb.ca/view/SMP0126542Drug actionSegesterone acetate, also known as Annovera, is a synthetic progestin derived from 19-norprogesterone. This drug is very potent; it mediates progestational activity 100 times higher than that of progesterone. It is used as a contraceptiv...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Ulipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalIt also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity … It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ESMYA® 5 MG COMPRIMIDOS, เอสมายาชนิดเม็ด 5 มก.Calcium carbimide
go.drugbank.com/drugs/DB09116ApprovedWithdrawnCalcium carbimide, sold as the citrate salt, is an alcohol-sensitizing agent. … Calcium carbimide was conceived as an alternative for the treatment of alcoholism with a reduced side effect profile either when it is consumed accompanied by alcohol or without it.
Synonyms: Cyanamide, calcium salt (1:1), methanediimine, calcium salt (1:1)Pramipexole Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126459Drug actionPramipexole is indicated for the management of Parkinson's disease and symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS). Pramipexole likely restores balance to the dopaminergic system, controlling the symp...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortNeuronal Dopamine Gs Cascade
smpdb.ca/view/SMP0126952PhysiologicalWhile IP3 is known to interact with the IP3 receptors at the endoplasmic reticulum (ER) and results in intracellular calcium release, DAG is best known for its role in the activation of protein kinase
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGemigliptin
go.drugbank.com/drugs/DB12412InvestigationalGemigliptin is under investigation in Type 2 Diabetes Mellitus. Gemigliptin has been investigated for the treatment of Cancer and Cisplatin Adverse Reaction.
Categories: metformin and gemigliptin, Heterocyclic Compounds, 1-RingAripiprazole Dopamine agonist Action Pathway
smpdb.ca/view/SMP0126454Drug actionAripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome....
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortNorgestrel Action Pathway
smpdb.ca/view/SMP0126522Drug actionNorgestrel is a synthetic progestin that has 2 stereoisomers, the active one is called levonorgestrel and the other one is dextronorgestrel. This drug is used in combination with ethinyl estradiol for oral contraception and prevention of...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Drospirenone Action Pathway
smpdb.ca/view/SMP0126538Drug actionDrospirenone is a synthetic progestin commonly found in popular oral contraceptives like Yaz, Angeliq, and Loryna. This drug is also indicated to control acne, menopause-associated symptoms, and premenstrual dysphoric disorder (PMDD) whe...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12