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Displaying results 1041 - 1050 of 10000 in total
  1. Drug

    Nabumetone

    go.drugbank.com/drugs/DB00461
    Approved

    [label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. … [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.

    Categories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Synonyms: 4-(6-Methoxy-2-naphthyl)-2-butanone, 4-(6-Methoxy-2-naphthalenyl)-2-butanone
  2. Target

    Interleukin-10

    go.drugbank.com/bio_entities/BE0002484
    TargetHumans

    Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetram...

    Polypeptides: Interleukin-10Synonyms: IL-10
  3. Target

    Aquaporin-10

    go.drugbank.com/bio_entities/BE0018706
    TransporterHumans

    Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11573934, PubMed:12084581, PubMed:217338...

    Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10
  4. Drug

    Salicylic acid

    go.drugbank.com/drugs/DB00936
    ApprovedInvestigationalVet approved

    It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.

    Synonyms: 2-Carboxyphenol, 2-Hydroxybenzoic acidMixtures: Soderm 0,5 mg/g + 20 mg/g Lösung zur Anwendung auf der Haut, ULTRALAN CRINALE SOLUSYON, 20 ML
  5. Drug

    Tafamidis

    go.drugbank.com/drugs/DB11644
    ApprovedInvestigational

    [A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]

    Synonyms: 2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid, 6-BENZOXAZOLECARBOXYLIC ACID, 2-(3,5-DICHLOROPHENYL)-Categories: Heterocyclic Compounds, 2-Ring
  6. Drug

    Bedaquiline

    go.drugbank.com/drugs/DB08903
    ApprovedInvestigational

    [A261856,A261861] It is the first drug that was approved in the last 40 years by the FDA for TB unresponsive to current treatments on the market. … [A261861] Bedaquiline was approved by the FDA on December 28, 2012, to treat pulmonary MDR-TB, following favorable results in multiple pre-clinical and clinical studies.

    Synonyms: 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-olCategories: Heterocyclic Compounds, 2-Ring
  7. Drug

    Chlorpropamide

    go.drugbank.com/drugs/DB00672
    ApprovedWithdrawn

    Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. … Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33).

    Synonyms: 1-(p-chlorobenzenesulfonyl)-3-propylurea, 1-(p-chlorophenylsulfonyl)-3-propylureaProducts: ORBİN 250 MG TABLET, 100 ADET, ORBİN 250 MG TABLET, 40 ADET
  8. Drug

    Glimepiride

    go.drugbank.com/drugs/DB00222
    ApprovedInvestigational

    Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes to lower blood glucose levels. … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control.

    Mixtures: DUERID 30/2 MG TABLET, 30 ADET, DUERID 30/2 MG TABLET, 90 ADETProducts: GLIMAX 1 MG TABLET, 60 ADET, TIDECA 1 MG TABLET, 30 TABLET
  9. Drug

    Sulbactam

    go.drugbank.com/drugs/DB09324
    ApprovedInvestigational

    [L50131] When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.[A263296]

    Synonyms: (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide, (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxideMixtures: BACTAMED 500 MG/250 MG IM IV ENJEKTABL TOZ IÇEREN FLAKON, 10 ADET, AMPİSİD 500 MG/250 MG IM ENJEKSİYONLUK TOZ, 1 ADET
  10. Drug

    Vismodegib

    go.drugbank.com/drugs/DB08828
    ApprovedInvestigational

    In July 2013, it was approved by the EMA, and since then, it has been approved by several other countries.[A7370,A258618,L45803] … However, dysregulated or aberrant Hedgehog signaling has been associated with basal cell carcinoma pathogenesis.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-