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Displaying results 1071 - 1080 of 10000 in total
  1. Drug

    Lonafarnib

    go.drugbank.com/drugs/DB06448
    ApprovedInvestigational

    [A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … for localization to the nuclear membrane, lonafarnib inhibits progerin accumulation and improves symptoms in HGPS patients.

  2. Drug

    Atropine

    go.drugbank.com/drugs/DB00572
    ApprovedInvestigationalVet approved

    [A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible … [A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]

    Mixtures: Re-PB Hyos, Re-PB HyosProducts: SULFATO DE ATROPINA 0.1 %, ATROPINE SULFAT IE AMPUL 1 MG/ML, 10 ADET
  3. Drug

    Ethinylestradiol

    go.drugbank.com/drugs/DB00977
    ApprovedInvestigational

    [A191107] It was developed in an effort to create an estrogen with greater oral bioavailability. … [A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.

    Mixtures: Vienva TM, Vienva TMCategories: Sex Hormones and Modulators of the Genital System
  4. Target

    G protein-coupled receptor kinase 2

    go.drugbank.com/bio_entities/BE0000341
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed … Also able to mediate phosphorylation-independent desensitization of dopamine receptor DRD2 (By similarity)

    Polypeptides: G protein-coupled receptor kinase 2Synonyms: Beta-adrenergic receptor kinase 1
  5. Target

    Receptor tyrosine-protein kinase erbB-2

    go.drugbank.com/bio_entities/BE0000511
    TargetEnzymeHumans

    Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. … Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding.

    Polypeptides: Receptor tyrosine-protein kinase erbB-2Synonyms: Tyrosine kinase-type cell surface receptor HER2
  6. Target

    Taste receptor type 1 member 3

    go.drugbank.com/bio_entities/BE0000582
    TargetHumans

    Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). … The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359).

    Polypeptides: Taste receptor type 1 member 3Synonyms: Sweet taste receptor T1R3
  7. Target

    Insulin-like growth factor 1 receptor

    go.drugbank.com/bio_entities/BE0000858
    TargetHumans

    Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor … Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.

    Polypeptides: Insulin-like growth factor 1 receptorSynonyms: IGF-I receptor, Insulin-like growth factor I receptor
  8. Target

    C-C chemokine receptor type 5

    go.drugbank.com/bio_entities/BE0000911
    TargetHumans

    Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770) … Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.

    Polypeptides: C-C chemokine receptor type 5
  9. Target

    Growth factor receptor-bound protein 2

    go.drugbank.com/bio_entities/BE0000917
    TargetHumans

    Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). … Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232

    Polypeptides: Growth factor receptor-bound protein 2Function: ephrin receptor binding
  10. Target

    High affinity nerve growth factor receptor

    go.drugbank.com/bio_entities/BE0001039
    TargetHumans

    Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and … High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889).

    Polypeptides: High affinity nerve growth factor receptorSynonyms: Tyrosine kinase receptor, Tyrosine kinase receptor A