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Displaying results 1081 - 1090 of 10000 in total
  1. Drug

    Bosutinib

    go.drugbank.com/drugs/DB06616
    ApprovedInvestigational

    Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein. … [A6902,A261796,A261801] The first BCR-ABL inhibitor, [imatinib], was introduced over a decade ago as a breakthrough in CML management; however, emerging resistance to [imatinib] poses challenges in achieving

  2. Target

    Metal cation symporter ZIP8

    go.drugbank.com/bio_entities/BE0009901
    TransporterHumans

    Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). … With manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449).

    Synonyms: BCG-induced integral membrane protein in monocyte clone 103 protein
  3. Drug

    Mumps virus strain B level jeryl lynn live antigen

    go.drugbank.com/drugs/DB10316
    ApprovedInvestigational

    Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease.

    Mixtures: Priorix Pulver in einer Durchstechflasche und Lösungsmittel in einer Fertigspritze zur Herstellung einer Injektionslösung, Priorix - Tetra Pulver in einer Durchstechflasche und Lösungsmittel in einer Fertigspritze zur Herstellung einer Injektionslösung
  4. Drug

    Ethionamide

    go.drugbank.com/drugs/DB00609
    ApprovedInvestigationalWithdrawn

    A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)

  5. Indication

    Degenerative Joint Disease of Hip

    go.drugbank.com/conditions/DBCOND0110588
    Drugs: Diacerein
    Synonyms: Osteoarthritis in the Hip Joint
  6. Indication

    Immune Thrombocytopenia (ITP)

    go.drugbank.com/conditions/DBCOND0035132
    Drugs: Azathioprine · Cortisone acetate · Cyclosporine · Dexamethasone · Hydrocortisone · Hydrocortisone succinate +6 more
    Synonyms: Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
  7. Drug

    Gadoteridol

    go.drugbank.com/drugs/DB00597
    ApprovedInvestigational

    [A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs) that was mandated by the EMA to replace linear gadolinium-based contrast agents due to concerns about retained … gadolinium in the brain.

    Categories: Compounds used in a research, industrial, or household setting
  8. Drug

    Potassium

    go.drugbank.com/drugs/DB14500
    ApprovedInvestigational

    They are available in an assortment of tablet, injection, and other forms, depending on the setting and condition being treated. … Potassium is often a key ingredient for intravenous fluids, given to patients in clinical settings for rehydration, nutrition, and replenishment of electrolytes.

    Mixtures: Multi II IV Vi Tab, Vc II
  9. Drug

    Toripalimab

    go.drugbank.com/drugs/DB15043
    ApprovedInvestigational

    It was first approved in China in December 2018 for the treatment of unresectable or metastatic melanoma in previously treated patients. … The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance.

  10. Drug

    Netarsudil

    go.drugbank.com/drugs/DB13931
    ApprovedInvestigational

    Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous … humour outflow to act as an inhibitor to the rho kinase and norepinephrine transporters found there as opposed to affecting protaglandin F2-alpha analog like mechanisms in the unconventional uveoscleral