Search

Displaying results 101 - 110 of 180 in total
  1. Target

    P-type Ca(2+) transporter

    go.drugbank.com/bio_entities/BE0009164
    TargetPlasmodium falciparum

    Synonyms: Sarcoplasmic and endoplasmic reticulum Ca-ATPase
  2. Target

    Zinc transporter ZIP6

    go.drugbank.com/bio_entities/BE0009887
    TransporterTargetHumans

    When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). … Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed

    Synonyms: Zrt- and Irt-like protein 6
  3. Target

    Thioredoxin reductase

    go.drugbank.com/bio_entities/BE0010144
    TargetMouse

    Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. … Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.

    Synonyms: Thioredoxin and glutathione reductase
  4. Target

    Stabilin-1

    go.drugbank.com/bio_entities/BE0010944
    TargetHumans

    Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system

    Synonyms: Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
  5. Target

    F-box/WD repeat-containing protein 1A

    go.drugbank.com/bio_entities/BE0021224
    TargetHumans

    SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169 … Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267

    Synonyms: F-box and WD repeats protein beta-TrCP
  6. Target

    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000377
    TargetHumans

    Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939 … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion

    Synonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  7. Target

    Cytohesin-2

    go.drugbank.com/bio_entities/BE0002654
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). … The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity)

    Synonyms: PH, SEC7 and coiled-coil domain-containing protein 2
  8. Target

    Excitatory amino acid transporter 3

    go.drugbank.com/bio_entities/BE0001054
    TargetTransporterHumans

    Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:26690923, PubMed:8857541). … Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity)

    Synonyms: Neuronal and epithelial glutamate transporter
  9. Target

    Ribosomal protein S6 kinase alpha-4

    go.drugbank.com/bio_entities/BE0004614
    TargetHumans

    Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. … that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes.

    Synonyms: Nuclear mitogen- and stress-activated protein kinase 2
  10. Target

    Zinc transporter ZIP12

    go.drugbank.com/bio_entities/BE0009897
    TransporterHumans

    May play a role in neurulation and neurite extension. … May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis

    Synonyms: Zrt- and Irt-like protein 12