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D-Glyceric Acidura
smpdb.ca/view/SMP0000529DiseaseD-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. … Defects in the enzyme will lead to accumulations of D-glyceric acid in tissues and biofluids.
Drugs: NADH · ATP · sn-glycerol 3-phosphate · Flavin adenine dinucleotide · Palmitic Acid · Glycerin +1 moreEnzymes: Glycerol kinase, Glycerol-3-phosphate dehydrogenase, mitochondrialGlycerin Drug Metabolism
smpdb.ca/view/SMP0130649MetabolicGlycerin passes through the liver and is then excreted from the body mainly through the kidney. … Glycerin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: GlycerinPeginterferon alfa-2a Action Pathway
smpdb.ca/view/SMP0125981Drug actionPeginterferon alfa-2a activate interferon alpha receptors 1 and 2 (IFNAR1 and IFNAR2) which are associated with tyrosine kinase 2 (TYK2) and JAK1 respectively. … They act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation.
Drugs: Peginterferon alfa-2aEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Peginterferon alfa-2b Action Pathway
smpdb.ca/view/SMP0126026Drug actionIts immunomodulatory effects are the enhancement of the phagocytic activity, the activation of NK cells, the stimulation of cytotoxic T-lymphocytes, and the upregulation of the Th1 T-helper cell subset … It is also used as an adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of definitive surgical resection.
Drugs: Peginterferon alfa-2bEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Interferon beta-1a Action Pathway
smpdb.ca/view/SMP0126027Drug actionThey act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation. … These transphosphorylate themselves and phosphorylate the IFNAR and IFNAR2c. This receptor complex also phosphorylates STAT3 homodimers.
Drugs: Interferon beta-1aEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Triflusal Action Pathway (new)
smpdb.ca/view/SMP0126547Drug actionDue to the anticoagulant and antiplatelet nature, herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Triflusal is administered orally and acts as an antithrombotic anticoagulant that irreversibly inhibits cyclooxygenase-1(COX-1) also known as prostaglandin g/h synthase 1.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Mesoheme +2 moreEnzymes: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ACardiolipin Biosynthesis CL(10:0/10:0/14:0/21:0)
smpdb.ca/view/SMP0175412MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicCardiolipin Biosynthesis CL(10:0/10:0/17:0/19:0)
smpdb.ca/view/SMP0175481MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicCardiolipin Biosynthesis CL(10:0/10:0/17:0/21:0)
smpdb.ca/view/SMP0175483MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicCardiolipin Biosynthesis CL(10:0/10:0/17:0/i-22:0)
smpdb.ca/view/SMP0175496MetabolicSixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic
Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphateEnzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic