Search
Tagraxofusp
go.drugbank.com/drugs/DB14731ApprovedInvestigationalIt is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_. … Tagraxofusp is a CD123-directed cytotoxin.
Categories: Proteins, Recombinant ProteinsSynonyms: Diphtheria toxin-il-3 fusion protein targeting IL-3 receptorLerodalcibep
go.drugbank.com/drugs/DB19071ApprovedInvestigationalLerodalcibep is a recombinant fusion protein that binds to and inhibits proprotein convertase subtilisin kexin type 9 (PCSK9). … [L54738] PCSK9 is a protein that binds to and promotes the degradation of low-density lipoprotein receptors (LDLRs), which are expressed on hepatocytes regulates circulating LDL levels.
Categories: Proteins, Recombinant ProteinsSynonyms: Protein lib003 (recombinant human proprotein convertase subtilisin/kexin type 9 ligand-binding tenth fibronectin type iii domain) fusion protein with peptide (synthetic 6-amino acid linker) fusion protein, Engineered binding protein (1-96) anti-(human proprotein convertase subtilisin/kexin type 9), derived from human tenth fibronectin type iii domain, fused via peptidyl linker (97gsgsgs102) to human serumSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
go.drugbank.com/bio_entities/BE0002326TargetHumansPP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). … Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).
Polypeptides: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformSynonyms: Replication protein C, RP-CSerine/threonine-protein kinase N2
go.drugbank.com/bio_entities/BE0009521TargetHumansPKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. … Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747)
Polypeptides: Serine/threonine-protein kinase N2Synonyms: Protein kinase C-like 2, Protein-kinase C-related kinase 2Nuclear migration protein nudC
go.drugbank.com/bio_entities/BE0009030TargetHumansPlays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokine...
Polypeptides: Nuclear migration protein nudCSynonyms: Nuclear distribution protein C homologCytochrome b-c1 complex subunit 8
go.drugbank.com/bio_entities/BE0003857TargetHumansThe respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c
Synonyms: Ubiquinol-cytochrome c reductase complex 9.5 kDa protein, Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C14-3-3 protein zeta/delta
go.drugbank.com/bio_entities/BE0001174TargetHumansAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763,
Polypeptides: 14-3-3 protein zeta/deltaSynonyms: Protein kinase C inhibitor protein 1Diacylglycerol acyltransferase/mycolyltransferase Ag85C
go.drugbank.com/bio_entities/BE0001688TargetMycobacterium tuberculosisThe antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine
Synonyms: Fibronectin-binding protein C, Fbps C14-3-3 protein beta/alpha
go.drugbank.com/bio_entities/BE0008974TargetHumansAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.
Polypeptides: 14-3-3 protein beta/alphaSynonyms: Protein kinase C inhibitor protein 1, Protein 1054activator protein 1
go.drugbank.com/bio_entities/BE0004924TargetHumansComponent of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. … This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I.
Polypeptides: Protein c-Fos, Jun dimerization protein 2Synonyms: Protein TREB36, Activator protein 1