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Leflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Synonyms: 4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamideProducts: SANLEF (20 MG), ARAVA ( 20 MG)Pralatrexate
go.drugbank.com/drugs/DB06813ApprovedInvestigational[A246693] Compared to methotrexate, pralatrexate has better accumulation in cancer cells. … [A246703] Pralatrexate was approved by the FDA on September 24, 2009.
Synonyms: 10-Propargyl-10-deazaaminopterin, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acidProducts: DIFOLTA 20 MG/ML SOLUCION PARA INFUSION, SOLUTION FOR INFUSION 20MG/MLTetracosactide
go.drugbank.com/drugs/DB01284ApprovedInvestigationalThe complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration. … ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.
Products: Synacthen 0,25 mg/1 ml Ampulle, SYNACTHEN DEPOT 1 MG AMPUL, 1 ADETMycophenolic acid
go.drugbank.com/drugs/DB01024ApprovedInvestigational[A249180,A249185] Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until … [A249175] This regimen can be used in place of the older anti-proliferative [azathioprine] due to its stronger immunosuppressive potency.
Synonyms: (e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acidProducts: MYFORTIC (180 MG ), MYFORTIC 180 MGStavudine
go.drugbank.com/drugs/DB00649ApprovedInvestigationalA dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Mixtures: TRIVIRO LNS® LAMIVUDINA 150 MG NEVIRAPINA 200 MG ESTAVUDINA 40 MG, CIPLABUDINA ES 30Categories: Antivirals used in combination for the treatment of HIV infectionsNitrendipine
go.drugbank.com/drugs/DB01054ApprovedWithdrawnIt is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
Mixtures: Baroprine 10 mg/20 mg Tabletten, ENIT 10 MG/20 MG TABLET, 30 ADETProducts: CONETRIN 20 MG, CONETRIN 10 MGCyproheptadine
go.drugbank.com/drugs/DB00434ApprovedInvestigational[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome.
Synonyms: 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidineProducts: Euro-cyproheptadine 4 Mg/tablet, PRAKTEN 2 MG/5 ML ŞURUP, 240 MLEtidronic acid
go.drugbank.com/drugs/DB01077ApprovedInvestigational[A203111] Etidronic acid was granted FDA approval on 1 September 1977.[L13901] … [A1923] Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]
Products: DIDRONAT 200 MG TABLET, 60 ADET, DIDRONAT 400 MG TABLET, 30 ADETMefenamic acid
go.drugbank.com/drugs/DB00784ApprovedIt is an inhibitor of cyclooxygenase.
Synonyms: N-2,3-xylylanthranilic acid, N-(2,3-xylyl)-2-aminobenzoic acidProducts: ROLADOL 50 MG KAPSUL, 10 ADET, PONSTAN 50 MG/ 5ML 125 ML SURUPTerfenadine
go.drugbank.com/drugs/DB00342ApprovedWithdrawnIn the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Products: TERFENADINA TABLETAS 60 MG, Seldane Sus 6mg/ml