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Not a candidate for hedgehog pathway inhibitor therapy
go.drugbank.com/conditions/DBCOND0145496Drugs: CemiplimabSynonyms: Not a candidate for hedgehog pathway inhibitor therapyAzithromycin
go.drugbank.com/drugs/DB00207ApprovedInvestigationalAzithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. … In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: POLVO PARA RECONSTRUIR A SUSPENSION ORAL, ALENAT ® POLVO PARA RECONSTITUIR A SUSPENSIÓN ORALZinc sulfate
go.drugbank.com/drugs/DB09322ApprovedInvestigationalIt is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. … Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol".
Mixtures: Zincfrin A, One-A-day Advance Men'sCategories: Skin and Mucous Membrane AgentsFosaprepitant
go.drugbank.com/drugs/DB06717ApprovedInvestigationalFosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. … It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Categories: Substance P/Neurokinin-1 Receptor Antagonist, Neurokinin 1 AntagonistsProducts: APRITANT IV® 150 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE, PREQUIM-FMorphine
go.drugbank.com/drugs/DB00295ApprovedInvestigationalMorphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … [A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diolPleckstrin homology domain-containing family A member 4
go.drugbank.com/bio_entities/BE0001278TargetHumansBinds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides
Polypeptides: Pleckstrin homology domain-containing family A member 4Synonyms: PH domain-containing family A member 4Pleckstrin homology domain-containing family A member 1
go.drugbank.com/bio_entities/BE0003262TargetHumansBinds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane
Polypeptides: Pleckstrin homology domain-containing family A member 1Synonyms: PH domain-containing family A member 1Potassium voltage-gated channel subfamily A member 4
go.drugbank.com/bio_entities/BE0004502TargetHumansLikewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368) … Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559).
Polypeptides: Potassium voltage-gated channel subfamily A member 4A disintegrin and metalloproteinase with thrombospondin motifs 4
go.drugbank.com/bio_entities/BE0004687EnzymeTargetHumansCould be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease … Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391).
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4Potassium voltage-gated channel subfamily A member 2
go.drugbank.com/bio_entities/BE0004715TargetHumansIn contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). … Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity)
Polypeptides: Potassium voltage-gated channel subfamily A member 2