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Baricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigationalBy inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses. … [L41760] Baricitinib was first approved by the European Commission (EC) in February 2017 for the treatment of rheumatoid arthritis in adults [A248395] and was later approved by the FDA in 2018.
Categories: Antineoplastic and Immunomodulating AgentsProducts: OLUMIANT FILM-COATED TABLET 2MG, Olumiant 2mg Film-Coated TabletsGuselkumab
go.drugbank.com/drugs/DB11834ApprovedInvestigationalDeveloped by Janssen, the subcutenous injection form of guselkumab was approved in July 2017 under the market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis. … In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological manifestations of psoriasis.
Categories: Amino Acids, Peptides, and Proteins, Skin and Mucous Membrane AgentsProducts: TREMFYA 100MG/ML SOLUTION FOR INJECTION, Tremfya One-Press 100mg/ml Solution for InjectionSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
go.drugbank.com/bio_entities/BE0000423TargetTransporterHumansTransports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766)
Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Drotrecogin alfa
go.drugbank.com/drugs/DB00055ApprovedWithdrawnIt is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. … Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.
Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansProducts: Xigris (20mg/vial), Xigris (5mg/vial)Tilactase
go.drugbank.com/drugs/DB13761ApprovedInvestigationalTilactase is a beta-D-galactosidase obtained from _Aspergillus oryzae_. It is produced as a chewable tablet that has to be taken before the consumption of a lactose-containing meal. … [A27172] The beta-D-galactosidase us a large monomeric multi-domain enzyme of 985 residues that presents a catalytic (alpha/beta)8-barrel domain.
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismProducts: LACDIGEST 2250 U CIGNEME TABLETI, 100 TABLET, LACDIGEST 2250 U CIGNEME TABLETI, 50 TABLETAmbrosia trifida pollen
go.drugbank.com/drugs/DB10386ApprovedAmbrosia trifida pollen is the pollen of the Ambrosia trifida plant. Ambrosia trifida pollen is mainly used in allergenic testing.
Mixtures: Short and Giant Ragweed Pollen Mix, Pollens - Weeds and Garden Plants, Ragweed, Mixed AmbrosiaProducts: Pollens - Weeds and Garden Plants, Ragweed, Giant Ambrosia trifidaBone and Joint Infections
go.drugbank.com/conditions/DBCOND0051086Synonyms: Bone and joint infection, Bone and Joint InfectionsCirculatory collapse and shock
go.drugbank.com/conditions/DBCOND0025070Drugs: DopamineSynonyms: Circulatory collapse and shockFriction and Pressure Injuries
go.drugbank.com/conditions/DBCOND0052518Drugs: Fluocinolone acetonideSynonyms: Friction and Pressure InjuriesSigns and Symptoms, Respiratory
go.drugbank.com/conditions/DBCOND0034552Drugs: FenspirideSynonyms: Signs and Symptoms, Respiratory, Respiratory signs and symptoms NEC