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Displaying results 1111 - 1120 of 10000 in total
  1. Target

    Schistosome calcium ion (Ca2+) channels

    go.drugbank.com/bio_entities/BE0004851
    TargetSchistosoma

  2. Indication

    Depression, Bipolar

    go.drugbank.com/conditions/DBCOND0030402
    Drugs: Lithium cation · Lurasidone
    Synonyms: Bipolar I Depression
  3. Indication

    Human Immunodeficiency Virus Type 1 (HIV-1)

    go.drugbank.com/conditions/DBCOND0042885
    Drugs: Cabotegravir · Doravirine · Enfuvirtide · Rilpivirine
    Synonyms: HIV-I
  4. Drug

    Threonine

    go.drugbank.com/drugs/DB00156
    ApprovedInvestigationalNutraceutical

    An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.

    Synonyms: L-2-Amino-3-hydroxybutyric acid, L-α-amino-β-hydroxybutyric acidMixtures: TRAVASOL SOLUCION 8.5% CON ELECTROLITOS, PF K-CAMINE %8 AMINO ASIT IV INFUZYON ICIN COZELTI, 1000 ML (SETLI)
  5. Target

    Calcium/calmodulin-dependent protein kinase type 1D

    go.drugbank.com/bio_entities/BE0004324
    TargetHumans

    Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and r...

    Synonyms: CaM kinase I delta, CaM-KI delta
  6. Drug

    Equecabtagene autoleucel

    go.drugbank.com/drugs/DB19016
    Investigational

    Synonyms: CAR) targeting human B cell maturation antigen (BCMA), autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (
  7. Target

    Kynurenine--oxoglutarate transaminase 1

    go.drugbank.com/bio_entities/BE0000273
    TargetEnzymeHumans

    Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic exci...

    Synonyms: Kynurenine aminotransferase I, Kynurenine--oxoglutarate transaminase I
  8. Target

    Activin receptor type-1-like

    go.drugbank.com/bio_entities/BE0000459
    TargetHumans

    Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Synonyms: TSR-I, TGF-B superfamily receptor type I
  9. Drug

    Sotorasib

    go.drugbank.com/drugs/DB15569
    ApprovedInvestigational

    [A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s.[A235168] It is the first experimental KRAS inhibitor. … Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.

    Synonyms: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one, Kras G12C inhibitor 9Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  10. Drug

    Mavacamten

    go.drugbank.com/drugs/DB14921
    ApprovedInvestigational

    It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. … [A248440] Mavacamten was also approved by Health Canada in October 2022 and by EMA in July 2023 for the same indication.[L44106,L47471]

    Synonyms: 6-(((1S)-1-Phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 tetrahydropyrimidine-2,4-dioneCategories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 Substrates