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Displaying results 1151 - 1160 of 10000 in total
  1. Drug

    Rabeprazole

    go.drugbank.com/drugs/DB01129
    ApprovedInvestigational

    Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. … Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.

    Categories: Cytochrome P-450 Substrates, 2-PyridinylmethylsulfinylbenzimidazolesProducts: PARIET ® TABLETAS DE 20 MG, Raberprazole Sodium D/r
  2. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0000366
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  3. Target

    Leukotriene A-4 hydrolase

    go.drugbank.com/bio_entities/BE0001680
    TargetHumans

    Can utilize LTA5 less effectively as a substrate than LTA4, and produce LTB5 (PubMed:2996528). … addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a

    Polypeptides: Leukotriene A-4 hydrolaseSynonyms: Leukotriene A(4) hydrolase
  4. Target

    Acetyl-coenzyme A synthetase

    go.drugbank.com/bio_entities/BE0001916
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.

    Polypeptides: Acetyl-coenzyme A synthetase
  5. Target

    Nucleoside diphosphate kinase A

    go.drugbank.com/bio_entities/BE0003106
    TargetEnzymeHumans

    Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore … May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing (

    Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A
  6. Target

    Stringent starvation protein A

    go.drugbank.com/bio_entities/BE0003260
    TargetYersinia pestis

    Polypeptides: Stringent starvation protein ASynonyms: Putative stringent starvation protein A, Regulator of transcription stringent starvation protein A
  7. Target

    Poly(A) polymerase alpha

    go.drugbank.com/bio_entities/BE0004515
    TargetHumans

    Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. … May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus

    Polypeptides: Poly(A) polymerase alpha
  8. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008382
    TargetEscherichia coli (strain K12)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:12051842, PubMed:18642932,

    Polypeptides: DNA gyrase subunit A
  9. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008385
    TargetStaphylococcus aureus

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  10. Target

    Repulsive guidance molecule A

    go.drugbank.com/bio_entities/BE0018257
    TargetHumans

    It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8

    Polypeptides: Repulsive guidance molecule ASynonyms: RGM domain family member A