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Nirsevimab
go.drugbank.com/drugs/DB16258ApprovedInvestigational[L44146] It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry process, and neutralizes several RSV A and B strains. … [A254691] This is due to a modification in the Fc region of nirsevimab that grants it a longer half-time compared to typical monoclonal antibodies.
Categories: Respiratory Syncytial Virus Anti-F Protein Monoclonal AntibodySynonyms: Immunoglobulin g1-kappa, anti-(human respiratory syncytial virus fusion glycoprotein f0 (protein f))human monoclonal antibody.gamma.1 heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4, *01 (90.1%)) (8.8.19) (1-126) -homo sapiens ighg1*03Methylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125204Drug actionMethylphenidate, known commonly as Ritalin, is a central nervous system stimulant used mainly for ADHD, but also for narcolepsy. ADHD is caused by an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Bupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionBupropion, known as the brand name Wellbutrin, is a norepinephrine/dopamine reuptake inhibitor (NDRI) used most commonly as a treatment for major depressive disorder (MDD), and seasonal affective disorder (SAD). It can also be used as a ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortMazindol Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126988Drug actionMazindol, commonly known as Sanorex, is a sympathomimetic used to treat Duchenne muscular dystrophy. It has similar side effects to amphetamine but is less toxic. This drug can be used as a short-term treatment of obesity when combined w...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126990Drug actionLisdexamfetamine, known commonly as Vyvanse, is a prodrug of amphetamine paired with lysine and used mainly for treating ADHD and binge eating disorders. The drug was engineered to be abuse-resistant with a delayed release. ADHD is cause...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Dextroamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126994Drug actionDextroamphetamine, known commonly as Adderall, is a drug related to amphetamine and is used mainly for treating ADHD and narcolepsy. The drug was approved by the FDA in 2001 for treating ADHD, but the exact mechanisms for its effects are...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Serdexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0127003Drug actionSerdexmethylphenidate, known commonly combined with dexmethylphenidate as Azstarys, is a prodrug of dexmethylphenidate (CNS stimulant) used for first-line treatment of ADHD. ADHD is caused by an abnormality in the dopamine transporter ge...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Dexmethylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0127004Drug actionDexmethylphenidate, known commonly combined with Serdexmethylphenidate as Azstarys, is a form of methylphenidate (CNS stimulant) used for first-line treatment of ADHD. ADHD is caused by an abnormality in the dopamine transporter gene (DA...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Sibutramine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0127006Drug actionSibutramine, commonly known as Meridia or Reductil, is a norepinephrine, serotonin and dopamine reuptake inhibitor used for the treatment of obesity. This drug was withdrawn from US and Canadian markets for increased risk of heart attack...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Droxidopa
go.drugbank.com/drugs/DB06262ApprovedInvestigationalEurope. … Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S.
Synonyms: L-DOPS, L-DihydroxyphenylserineCategories: Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-2 Receptor Agonists