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Nomifensine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0127002Drug actionNomifensine, formerly known as Merital capsules, is a dopamine reuptake inhibitor drug that was removed from the market in 1986 for increased incidence of hemolytic anemia. The drug was originally used to treat depression. Nomifensine st...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Allylestrenol
go.drugbank.com/drugs/DB01431InvestigationalIt is widely marketed throughout Europe, including Russia and many other European countries, and is also available in Japan, Hong Kong, India, Bangladesh, Indonesia, and much of Southeast Asia, though … A synthetic steroid with progestational activity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 17α-allylestr-4-en-17β-ol, 3-deketo-17α-allyl-19-nortestosteroneEdoxudine
go.drugbank.com/drugs/DB13421ApprovedWithdrawnEdoxudine is a deoxythymidine analog with activity against herpes simplex virus. It is a potent and selective inhibitor of herpes simplex virus type 1 and 2. … It was later recognized to be effective in vivo in a preclinical model of keratitis caused by herpes virus.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2'-Deoxy-5-ethyluridine, 5-Ethyl-2'-deoxyuridineEtodolac
go.drugbank.com/drugs/DB00749ApprovedInvestigationalVet approvedEtodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. … It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Synonyms: (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid, 1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acidMixtures: S-ETODUO 150/300 MG FİLM KAPLI TABLET, 10 ADET, S-ETODUO 150/300 MG FİLM KAPLI TABLET, 14 ADETDexloxiglumide
go.drugbank.com/drugs/DB04856InvestigationalDexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist in phase III testing by Rottapharm in Europe only, as U.S. trials have been discontinued. … As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more potent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesPropofol
go.drugbank.com/drugs/DB00818ApprovedInvestigationalVet approvedIV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. … Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia.
Mixtures: Anesthesia S/I-60, Anesthesia S/I-40Categories: P-glycoprotein inducers, Cytochrome P-450 SubstratesSennosides
go.drugbank.com/drugs/DB11365ApprovedInvestigationalIt is a weaker laxative than bisacodyl or castor oil[A177092]. … Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and empty the large intestine before surgery.
Salts: Sennosides A and BMixtures: Senna-S, Senexon-SGluconic Acid
go.drugbank.com/drugs/DB13180ApprovedInvestigationalGluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Mixtures: Isolyte S, Isolyte S pH 7.4Synonyms: D-Gluconic AcidSodium phosphate, dibasic
go.drugbank.com/drugs/DB14502ApprovedInvestigationalSynonyms: Phosphoric acid, sodium salt (1:2)Mixtures: ISOLYTE-S PH 7.4 PVC 500 ML(SETLI), ISOLYTE-S PH 7.4 PVC 1000 ML(SETLI)Ivosidenib
go.drugbank.com/drugs/DB14568ApprovedInvestigationalIvosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. … The drug is only effective in patients with a susceptible IDH1 mutation.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index