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Ajmaline
go.drugbank.com/drugs/DB01426ApprovedWithdrawnAn alkaloid found in the root of Rauwolfia serpentina, among other plant sources. … It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope.
Synonyms: (5aR,6S,8S,10S,11S,11aS,12aR,13R)-5-methyl-5a,6,8,9,10,11,11a,12-octahydro-5H-6,10:11,12a-dimethanoindolo[3,2-b]quinolizine-8,13-diolCategories: Antiarrhythmics, Class I, Heterocyclic Compounds, 2-RingDasiglucagon
go.drugbank.com/drugs/DB15226Approved[L39190] Severe hypoglycemia is an acute, life-threatening medical condition resulting from a profound drop in blood glucose levels. … severe hypoglycemia a year.
Infliximab
go.drugbank.com/drugs/DB00065ApprovedInvestigationalBy binding to both the soluble subunit and the membrane-bound precursor of TNF-α [A106], infliximab disrupts the interaction of TNF-α with its receptors and may also cause lysis of cells that produce TNF-α … Infliximab was first approved by the FDA in 1998 under the market name Remicade as an intravenous injection.
Synonyms: IMMUNOGLOBULIN G (HUMAN-MOUSE MONOCLONAL CA2 HEAVY CHAIN ANTI-HUMAN TUMOR NECROSIS FACTOR), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL CA2 LIGHT CHAIN, DIMERProducts: REMICADE 100MG PUL HER INF, INFLECTRA 100MG PLV F E KOTrypsin
go.drugbank.com/drugs/DB11237ApprovedInvestigationalVet approvedTrypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate [A27241]. … Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals.
Droxicam
go.drugbank.com/drugs/DB09215ApprovedWithdrawnDroxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of [DB00554].
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-RingLactulose
go.drugbank.com/drugs/DB00581ApprovedInvestigationalwithheld from patients diagnosed with PSE in a placebo study, the substance may just be one of many options available for treating constipation and its efficacy in managing PSE may never be formally confirmed … Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic
Synonyms: 4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructoseProducts: LACTUS SYRUP 66% w/v, FLOROLAC 670MG/ML LOES Z ESulconazole
go.drugbank.com/drugs/DB06820ApprovedSulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis … Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP1A2 InhibitorsLevoketoconazole
go.drugbank.com/drugs/DB05667ApprovedIt possesses most of the inhibitory effect towards steroidogenic enzymes, making it an attractive candidate for CS treatment with a potentially lower toxicity profile than its racemate. … Still, toxicity has limited its use, notably hepatic toxicity and a tendency to prolong the QT interval.[A244083] Levoketoconazole is one of two enantiomers present in racemic [ketoconazole].
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsPyrazinamide
go.drugbank.com/drugs/DB00339ApprovedInvestigationalA pyrazine that is used therapeutically as an antitubercular agent.
Synonyms: 2-carbamylpyrazine, 2-pyrazinecarboxamideMixtures: RINCURE ® 3 FDC TABLETAS CON PELICULA, PRO TB 4Status Epilepticus
go.drugbank.com/conditions/DBCOND0028922Synonyms: Grand mal status, Grand mal status, epileptic