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Gliclazide Action Pathway (New)
smpdb.ca/view/SMP0126302Drug actionThe depolarization opens the voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to the exocytosis of insulin-containing granules.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Nateglinide Action Pathway (New)
smpdb.ca/view/SMP0126392Drug actionIn consequence, the increased concentration of calcium results in the stimulation of the calcium-dependent exocytosis of insulin granules. … This results in the depolarization of the cell and the opening of the L-type calcium channels.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Nicotinic Acetylcholine
smpdb.ca/view/SMP0130480PhysiologicalOn the other hand, the entry of calcium acts, either directly or indirectly, on different intracellular cascades.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Physostigmine Action Pathway (new)
smpdb.ca/view/SMP0126616Drug actionPhysostigmine is a cholinesterase inhibitor used to treat glaucoma, once administered it is rapidly absorbed and can travel across membranes even the blood-brain barrier. Physostigmine acts on the acetylcholinesterase enzyme and inhibits...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Tacrine Action Pathway (new)
smpdb.ca/view/SMP0126621Drug actionTacrine an anticholinesterase drug used primarily in the treatment of Alzheimer's disease, the drug also counters the effects of muscle relaxants, respiratory stimulants and other central nervous disorders. Its mechanism of action is not...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Perphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126530Drug actionThis receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Digoxin Cardiac Action Pathway
smpdb.ca/view/SMP0125107Drug actionThe rise in calcium levels leads to prolongation of phase 4 and phase 0 of the cardiac action potential. … When an action potential arrives at the myocardium, it triggers L-type voltage gated calcium channels on the membrane which causes an influx of Ca2+ from the extracellular space into the cytosol.
Enzymes: Sodium/calcium exchanger 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Modafinil Action Pathway
smpdb.ca/view/SMP0125075Drug actionModafinil is a non-amphetamine central nervous system (CNS) stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. The exact mechanism of action is unclear, although in vitro studies have ...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Cabergoline Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126670Drug actionCabergoline stimulates centrally-located dopaminergic D2- and D3-receptors. Cabergoline is a long-acting agonist with a high affinity for D2 receptors. It also exhibits: weak agonist activity (in order of decreasing binding affinities) o...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BQuinagolide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126673Drug actionNewer dopamine receptor agonists such as quinagolide and Cabergoline are shown to effectively inhibit prolactin secretion with improved efficacy over Bromocriptine. These drugs are effective in patients who are intolerant or resistant to...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B