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Grazoprevir Action Pathway
smpdb.ca/view/SMP0125958Drug actionThe lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. … NS5A, and NS5B.
Mefenamic Acid Action Pathway
smpdb.ca/view/SMP0000109Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … It can be used to relieve pain (analgesic) and reduce fever (antipyretic). Mefenamic acid can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2.
Drugs: Glutamic acid · Glutathione · Mefenamic acid · Dinoprostone · Calcium · Magnesium cation +5 moreTiaprofenic Acid Action Pathway
smpdb.ca/view/SMP0000705Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Tiaprofenic can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2.
Salicylate-Sodium Action Pathway
smpdb.ca/view/SMP0000708Drug actionIt can be used for relieving pain and reducing fever. Salicylate-sodium can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Salicylic acid +5 moreGemcitabine Metabolism Pathway (old)
smpdb.ca/view/SMP0000603Drug metabolismGemcitabine is phosphorylated into gemcitabine monophosphate by deoxycytidine kinase, which is then subsequently phosphorylated into the diphosphate and triphosphate nucleotides by UMP-CMP kinase and nucleoside … Gemcitabine enters the cell via sodium nucleoside co-transporters (SLC29A1, SLC28A1, and SLC28A3), where it acts through multiple mechanisms to produce a cytotoxic effect.
Acetylsalicylic Acid Action Pathway
smpdb.ca/view/SMP0000083Drug actionLike most other NSAIDs, aspirin exerts its therapeutic effects by inhibiting prostaglandin G/H synthase 1 and 2, better known as cyclooxygenase-1 and -2 or simply COX-1 and -2. … COX-1 and -2 catalyze the conversion of arachidonic acid to prostaglandin G2 and prostaglandin G2 to prostaglandin H2.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Magnesium cation +5 moreSalicylic Acid Action Pathway
smpdb.ca/view/SMP0000709Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Salicylic acid is also an important active metabolite of aspirin (acetylsalicylic acid). It can be used to reduce pain and fever.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Salicylic acid · Calcium · Magnesium cation +5 moremTOR Signaling pathway
smpdb.ca/view/SMP0535455SignalingmTOR is a serine/threonine kinase forming two distinct multiprotein complexes—mTORC1 (composed of mTOR, Raptor, PRAS40, DEPTOR, and mLST8) and mTORC2 (composed of mTOR, Rictor, mSIN1, Protor, DEPTOR, and … as rapamycin and its analogs—has shown efficacy in cancer and aging models but may also perturb immune function and metabolic homeostasis.
Enzymes: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENJoubert Syndrome
smpdb.ca/view/SMP0000582DiseaseJoubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and … The symptoms affect a variety of body parts in the patient, including apnea, ataxia brought on by hypotonia, abnormal eye movements and intellectual disability.
Enzymes: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENJoubert Syndrome
smpdb.ca/view/SMP0125809DiseaseJoubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and … The symptoms affect a variety of body parts in the patient, including apnea, ataxia brought on by hypotonia, abnormal eye movements and intellectual disability.
Enzymes: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN