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Zinc transporter ZIP11
go.drugbank.com/bio_entities/BE0009906TransporterHumansZinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechan...
Synonyms: Zrt- and Irt-like protein 11Protein phosphatase 1 regulatory subunit 15A
go.drugbank.com/bio_entities/BE0011888TargetHumansPlays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). … Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication (PubMed:31778897, PubMed:41747053).
Synonyms: Growth arrest and DNA damage-inducible protein GADD34Alpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1SPARC
go.drugbank.com/bio_entities/BE0002145TargetHumansBinds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. … There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Synonyms: Secreted protein acidic and rich in cysteineZinc transporter ZIP4
go.drugbank.com/bio_entities/BE0009894TransporterHumansAlso exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) … Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750).
Synonyms: Zrt- and Irt-like protein 4Zinc transporter ZIP3
go.drugbank.com/bio_entities/BE0009904TransporterHumansTransporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted m...
Synonyms: Zrt- and Irt-like protein 3Zinc transporter ZIP9
go.drugbank.com/bio_entities/BE0009905TransporterHumansThis pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). … Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737).
Synonyms: Zrt- and Irt-like protein 9Interphotoreceptor matrix proteoglycan 2
go.drugbank.com/bio_entities/BE0004942TargetHumansChondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor
Synonyms: Sialoprotein associated with cones and rods proteoglycanTransient receptor potential cation channel subfamily M member 5
go.drugbank.com/bio_entities/BE0020643TargetHumansdiacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release. … Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208).
Synonyms: MLSN1- and TRP-related gene 1 protein