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Displaying results 111 - 120 of 2873 in total
  1. Pathway

    Tolazamide Action Pathway

    smpdb.ca/view/SMP0126144
    Drug action

    This depolarization stimulates the calcium ion influx through voltage-sensitive calcium channels thus raising intracellular concentrations of calcium ions. … The higher concentration of intracellular calcium ions induces the secretion (exocytosis) of insulin into the blood. Tolazamide is administered as an oral tablet.

    Drugs: ATP · Tolazamide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  2. Pathway

    Glyburide Action Pathway

    smpdb.ca/view/SMP0126298
    Drug action

    Normally SUR1 closes in response to high glucose concentrations, the membrane potential of the cells becomes less negative, the cell depolarizes, voltage-gated calcium channels open, calcium ions enter … the cell, and the increased intracellular calcium concentration stimulates the release of insulin by exocytosis into the blood.

    Drugs: ATP · Glyburide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  3. Pathway

    Gliclazide Action Pathway (New)

    smpdb.ca/view/SMP0126302
    Drug action

    The depolarization opens the voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to the exocytosis of insulin-containing granules.

    Drugs: ATP · Gliclazide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  4. Pathway

    Nateglinide Action Pathway (New)

    smpdb.ca/view/SMP0126392
    Drug action

    In consequence, the increased concentration of calcium results in the stimulation of the calcium-dependent exocytosis of insulin granules. … This results in the depolarization of the cell and the opening of the L-type calcium channels.

    Drugs: ATP · Nateglinide · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  5. Pathway

    Nicotinic Acetylcholine

    smpdb.ca/view/SMP0130480
    Physiological

    On the other hand, the entry of calcium acts, either directly or indirectly, on different intracellular cascades.

    Drugs: Choline · Calcium · Magnesium cation · Acetylcholine
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  6. Pathway

    Physostigmine Action Pathway (new)

    smpdb.ca/view/SMP0126616
    Drug action

    Physostigmine is a cholinesterase inhibitor used to treat glaucoma, once administered it is rapidly absorbed and can travel across membranes even the blood-brain barrier. Physostigmine acts on the acetylcholinesterase enzyme and inhibits...

    Drugs: Choline · Physostigmine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  7. Pathway

    Tacrine Action Pathway (new)

    smpdb.ca/view/SMP0126621
    Drug action

    Tacrine an anticholinesterase drug used primarily in the treatment of Alzheimer's disease, the drug also counters the effects of muscle relaxants, respiratory stimulants and other central nervous disorders. Its mechanism of action is not...

    Drugs: Choline · Tacrine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  8. Pathway

    Perphenazine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126530
    Drug action

    This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Perphenazine · Dopamine · Levodopa +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  9. Pathway

    Digoxin Cardiac Action Pathway

    smpdb.ca/view/SMP0125107
    Drug action

    The rise in calcium levels leads to prolongation of phase 4 and phase 0 of the cardiac action potential. … When an action potential arrives at the myocardium, it triggers L-type voltage gated calcium channels on the membrane which causes an influx of Ca2+ from the extracellular space into the cytosol.

    Drugs: Digoxin · Potassium cation · Calcium
    Enzymes: Sodium/calcium exchanger 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
  10. Pathway

    Modafinil Action Pathway

    smpdb.ca/view/SMP0125075
    Drug action

    Modafinil is a non-amphetamine central nervous system (CNS) stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. The exact mechanism of action is unclear, although in vitro studies have ...

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Modafinil · Dopamine · Levodopa +2 more
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1