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Bromopride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126582Drug actionBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorBrexpiprazole Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126698Drug actionBrexpiprazole is predominantly, a 5-HT1A, D2, and D3 partial agonist and a 5-HT2A, 5-HT2B, 5-HT7, alpha1A, alpha1B, alpha1D, and alpha2C antagonist with a chemical formula of 7-{4-[4-(1-Benzothiophen-4 … dopamine D2 receptors, and antagonist activity at 5-HT2A receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorPaliperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126592Drug actionPaliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. … It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorHyperprolinemia Type II
smpdb.ca/view/SMP0125624DiseaseThis enzyme is responsible for catalyzing the dehydrogenation of 1-pyrroline-5-carboxylic acid or L-glutamic gamma-semialdehyde into L-glutamic acid. … Symptoms include hydroxyprolinuria and hyperglycinuria, and can include seizures and some amount of mental retardation.
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: D-amino-acid oxidaseOlanzapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126805Drug actionhallucinations, delusions, and disorganized speech, thought, and behavior. … lanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorTrifluoperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126561Drug actionTrifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating … system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorPromazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126483Drug actionPromazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. … Promazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorPimozide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126532Drug actionPimozide binds and inhibits the dopamine D2 receptor in the CNS. … It has a role as a H1-receptor antagonist, a serotonergic antagonist, a first generation antipsychotic, an antidyskinesia agent and a dopaminergic antagonist.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorMethotrimeprazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126562Drug actionMethotrimeprazine is a phenothiazine derivative, a first-generation antipsychotic, dopamine receptor antagonists (DRA) and a typical antipsychotic.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorHaloperidol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126593Drug actionFor oral administration, it is available as a tablet form and oral concentrate form. It is also available in a nasal spray formulation. … It is also used off-label for the management of chorea associated with Huntington's disease and for the treatment of intractable hiccups as it is a potent antiemetic.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptor