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Displaying results 111 - 120 of 2725 in total
  1. Pathway

    Glycine and Serine Metabolism

    smpdb.ca/view/SMP0000004
    Metabolic

    This pathway describes the synthesis and breakdown of several small amino acids, including glycine, serine, and cysteine. All of these compounds share common intermediates and almost all can be biosynthesized from one another. Serine and...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  2. Pathway

    Dihydropyrimidine Dehydrogenase Deficiency (DHPD)

    smpdb.ca/view/SMP0000179
    Disease

    Dihydropyrimidine Dehydrogenase Deficiency (DHPD; Thymine-uraciluria) is a rare autosomal recessive disorder caused by a mutation in the DPYD gene which codes for dihydropyrimidine dehydrogenase. A deficiency in this enzyme results in ac...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  3. Pathway

    Dimethylglycine Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000242
    Disease

    Dimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  4. Pathway

    Hyperglycinemia, Non-Ketotic

    smpdb.ca/view/SMP0000485
    Disease

    Nonketotic hyperglycinemia (GCE) is a rare inborn error of metabolism (IEM) and autosomal recessive disorder caused by a defective GLDC gene. GLDC encodes for the enzymes involved in the conversion of glycine to CO2, NH3 and hydroxymethy...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  5. Pathway

    3-Phosphoglycerate Dehydrogenase Deficiency

    smpdb.ca/view/SMP0125581
    Disease

    3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or h...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
  6. Target

    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

    go.drugbank.com/bio_entities/BE0001519
    TargetEscherichia coli (strain K12)

    Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (PubMed:1092681, PubMed:1092682).

  7. Target

    S-methylmethionine--homocysteine S-methyltransferase BHMT2

    go.drugbank.com/bio_entities/BE0002249
    TargetEnzymeHumans

    Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor

  8. Target

    S-adenosylmethionine synthase

    go.drugbank.com/bio_entities/BE0009188
    TargetPlasmodium falciparum (isolate 3D7)

    Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

  9. Target

    S-adenosylmethionine decarboxylase proenzyme

    go.drugbank.com/bio_entities/BE0000101
    TargetHumans

    Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels

  10. Target

    Thiopurine S-methyltransferase

    go.drugbank.com/bio_entities/BE0000987
    EnzymeTargetHumans

    the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine

    Function: S-adenosyl-L-methionine binding