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Zinc transporter ZIP12
go.drugbank.com/bio_entities/BE0009897TransporterHumansMay play a role in neurulation and neurite extension. … May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis
Synonyms: Zrt- and Irt-like protein 12Zinc transporter ZIP13
go.drugbank.com/bio_entities/BE0009900TransporterHumansFunctions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233).
Synonyms: Zrt- and Irt-like protein 13Zinc transporter ZIP1
go.drugbank.com/bio_entities/BE0009902TransporterHumansTransporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into...
Synonyms: Zrt- and Irt-like protein 1Scavenger receptor class B member 1
go.drugbank.com/bio_entities/BE0000189TargetTransporterHumansAlso facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. … Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).
Synonyms: CD36 and LIMPII analogous 1Tumor necrosis factor ligand superfamily member 13
go.drugbank.com/bio_entities/BE0010394TargetHumansCytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes
Synonyms: TNF- and APOL-related leukocyte expressed ligand 2Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
go.drugbank.com/bio_entities/BE0021514EnzymeHumansPhosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end … Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:
Synonyms: SAM domain and HD domain-containing protein 1C-C motif chemokine 2
go.drugbank.com/bio_entities/BE0001047TargetHumansSignals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). … Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674).
Synonyms: Monocyte chemotactic and activating factorSerine/threonine-protein kinase 16
go.drugbank.com/bio_entities/BE0009542TargetHumansMembrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates.
Synonyms: Myristoylated and palmitoylated serine/threonine-protein kinaseDNA-binding protein SMUBP-2
go.drugbank.com/bio_entities/BE0013009TargetHumans5' to 3' helicase that unwinds both RNA and DNA duplexes in an ATP-dependent reaction (Probable) (PubMed:19158098, PubMed:30218034).
Synonyms: DNA and RNA 5'-3' helicase IGHMBP2Amino acid transporter heavy chain SLC3A1
go.drugbank.com/bio_entities/BE0001130TransporterHumansSLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. … Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion.
Synonyms: Neutral and basic amino acid transport protein