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Displaying results 111 - 120 of 130 in total
  1. Pathway

    Solriamfetol Action Pathway

    smpdb.ca/view/SMP0126346
    Drug action

    Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). … Solriamfetol weakly binds to dopamine and norepinephrine transporters but not serotonin transporters.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Dopamine +8 more
  2. Pathway

    Safinamide Action Pathway

    smpdb.ca/view/SMP0126696
    Drug action

    The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mostly in the brain.

    Drugs: Pyridoxal phosphate · Ademetionine · Tyrosine · ATP · Sapropterin · Norepinephrine +9 more
  3. Pathway

    Levodopa Metabolism Pathway

    smpdb.ca/view/SMP0125329
    Metabolic

    Levodopa is an oral drug used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. It is a dopamine precursor and is used to synthesize dopamine in dopam...

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · NADH · Norepinephrine · Epinephrine +6 more
  4. Drug

    Chlorpheniramine

    go.drugbank.com/drugs/DB01114
    ApprovedInvestigational

    A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less dr...

    Mixtures: Hydrocodone Bitartrate and Chlorpheniramine Maleate, Hydrocodone Bitartrate and Chlorpheniramine Maleate SolutionCategories: Combined Inhibitors of Serotonin/Norepinephrine Reuptake
  5. Pathway

    Monoamine Oxidase-A Deficiency (MAO-A)

    smpdb.ca/view/SMP0000533
    Disease

    In another branch of tyrosine metabolism, the absence of MAO-A prevents the oxidation of norepinephrine and epinephrine into 3,4-dihydroxymandelaldehyde. … Since serotonin helps to regulate emotions and mood, with epinephrine and norepinephrine regulating stress, the unnecessary presence of the chemicals in the brain can lead to poor impulse control, aggression

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  6. Pathway

    Tyrosine Metabolism

    smpdb.ca/view/SMP0000006
    Metabolic

    Norepinephrine can then be converted to epinephrine (adrenaline) through the action of phenyethanolamine N-methyltransferase (PNMT). … Dopamine can also be converted to norepinephrine (noradrenaline) through the action of the enzyme known as dopamine beta hydroxylase (DBH).

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  7. Pathway

    Dopamine beta-Hydroxylase Deficiency

    smpdb.ca/view/SMP0000498
    Disease

    Dopamine beta-hydroxylase deficiency (or norepinephrine deficiency) is caused by mutation in the gene encoding dopamine beta-hydroxylase.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  8. Pathway

    Dopamine beta-Hydroxylase Deficiency

    smpdb.ca/view/SMP0125594
    Disease

    Dopamine beta-hydroxylase deficiency (or norepinephrine deficiency) is caused by mutation in the gene encoding dopamine beta-hydroxylase.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  9. Pathway

    Monoamine Oxidase-A Deficiency (MAO-A)

    smpdb.ca/view/SMP0125595
    Disease

    In another branch of tyrosine metabolism, the absence of MAO-A prevents the oxidation of norepinephrine and epinephrine into 3,4-dihydroxymandelaldehyde. … Since serotonin helps to regulate emotions and mood, with epinephrine and norepinephrine regulating stress, the unnecessary presence of the chemicals in the brain can lead to poor impulse control, aggression

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  10. Pathway

    Tyrosinemia Type I

    smpdb.ca/view/SMP0000218
    Disease

    Tyrosinemia type I, also known as fumarylacetoacetase or FAH deficiency, is the most severe type of tyrosinemia, a buildup of tyrosine in the body. It is caused by an autosomal recessive mutation in the the FAH gene that encodes for fuma...

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more