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Displaying results 111 - 120 of 597 in total
  1. Pathway

    Nicotine Action Pathway

    smpdb.ca/view/SMP0000431
    Drug action

    This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. … Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels.

    Drugs: NADH · ATP · Nicotine · Norepinephrine · Dopamine · Potassium cation +5 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Remifentanil Action Pathway

    smpdb.ca/view/SMP0000416
    Drug action

    and decrease in cAMP production. … Analgesia, anesthesia, and respiratory depression are a function of remifentanial’s action on these mu-type opioid receptors.

    Drugs: ATP · Norepinephrine · Remifentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Tramadol Action Action Pathway

    smpdb.ca/view/SMP0000671
    Drug action

    Tramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … Although tramadol is structurally related to codeine and morphine, it’s affinity for the mu receptor compared to other opioids is significantly less.

    Drugs: ATP · Tramadol · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Naloxone Action Pathway

    smpdb.ca/view/SMP0000688
    Drug action

    In recent study, naloxone shows that it can also bind to kappa and gamma-opioid receptors.

    Drugs: ATP · Norepinephrine · Dopamine · Naloxone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Methadone Action Pathway

    smpdb.ca/view/SMP0000408
    Drug action

    G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. … Methadone further acts as an antagonist at the NMDA receptor, reducting calcium influx and neuronal excitability.

    Drugs: NADH · ATP · Methadone · Norepinephrine · Dopamine · Potassium cation +3 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Citalopram Action Pathway

    smpdb.ca/view/SMP0000424
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: NADH · ATP · Citalopram · Norepinephrine · Dopamine · Potassium cation +5 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Heroin Action Pathway

    smpdb.ca/view/SMP0000407
    Drug action

    They are beta-endorphin, dynorphin, leu-enkephalin, and met-enkephalin. … Endorphins are regularly released in the brain and nerves, attenuating pain.

    Drugs: ATP · Morphine · Norepinephrine · Dopamine · Potassium cation · Calcium +2 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Levallorphan Action Pathway

    smpdb.ca/view/SMP0000683
    Drug action

    Levallorphan (also known as Lorfan and Naloxifan) is a type of medication that can be used for treating drug overdoses and respirotry depression. … Levallorphan can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron of central nerves system (CNS).

    Drugs: ATP · Norepinephrine · Levallorphan · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Buprenorphine Action Pathway

    smpdb.ca/view/SMP0000684
    Drug action

    and symptoms of withdrawal. … Buprenorphine, trade name subutex, suboxone, zubsolv and bunavail, is a partial agonist of mu-opioid receptors and a kappa-opioid receptor antagonist and is prescribed for opioid addiction to prevent cravings

    Drugs: ATP · Norepinephrine · Buprenorphine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Naltrexone Action Pathway

    smpdb.ca/view/SMP0000687
    Drug action

    Naltrexone (also known as ReVia and Vivitrol) is a competitive antagonist of mu-type opioid receptor in the central nervous system (CNS).

    Drugs: ATP · Norepinephrine · Naltrexone · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1