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Displaying results 111 - 120 of 178 in total
  1. Target

    Protein kinase C gamma type

    go.drugbank.com/bio_entities/BE0009588
    TargetHumans

    During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic

  2. Target

    Protein kinase C zeta type

    go.drugbank.com/bio_entities/BE0009589
    TargetHumans

    Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. … Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes.

  3. Target

    Transient receptor potential cation channel subfamily M member 3

    go.drugbank.com/bio_entities/BE0009808
    TransporterHumans

    Mediates Zn(2+) uptake into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion (By similarity). … Suggested to function as an ionotropic steroid receptor in beta-cell, indeed pregnenolone sulfate leads to Ca(2+) influx and enhanced insulin secretion.

  4. Target

    Diacylglycerol kinase

    go.drugbank.com/bio_entities/BE0009935
    TargetHumans

    Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity)

  5. Target

    Adenylate cyclase

    go.drugbank.com/bio_entities/BE0010179
    TargetHumans

    Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA … Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion.

  6. Target

    Cyclin-dependent kinases

    go.drugbank.com/bio_entities/BE0010231
    TargetHumans

    Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro) … CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).

  7. Target

    Pro-glucagon

    go.drugbank.com/bio_entities/BE0010345
    TargetHumans

    A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia.

  8. Target

    Tyrosine-protein phosphatase non-receptor type substrate 1

    go.drugbank.com/bio_entities/BE0010650
    TargetHumans

    Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.

  9. Target

    Nuclear receptor ROR-gamma

    go.drugbank.com/bio_entities/BE0013275
    TargetHumans

    Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity.

  10. Target

    Alpha-(1,3)-fucosyltransferase 7

    go.drugbank.com/bio_entities/BE0014260
    EnzymeTargetHumans

    May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of