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Displaying results 111 - 120 of 224 in total
  1. Drug

    Flupirtine

    go.drugbank.com/drugs/DB06623
    Investigational

    Flupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. It is not approved for use in the U.S. or Canada, but is currently in phase II trials for ...

    Salts: Flupirtine maleate
  2. Drug

    Esmirtazapine

    go.drugbank.com/drugs/DB06678
    Investigational

    Esmirtazapine, known by the standardized identifier SCH 900265, was under development by Organon to treat insomnia and vasomotor symptoms associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses sim...

    Salts: Esmirtazapine maleate
  3. Indication

    Severe Nausea and vomiting

    go.drugbank.com/conditions/DBCOND0021212
    Drugs: Perphenazine · Prochlorperazine
  4. Drug

    Amlodipine

    go.drugbank.com/drugs/DB00381
    ApprovedInvestigational

    Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyri...

    Salts: Amlodipine maleate
  5. Indication

    Male Breast Enlargement

    go.drugbank.com/conditions/DBCOND0080463
    Drugs: Tamoxifen
    Synonyms: Male Breast Enlargement, Breast enlargement male
  6. Pathway

    Transfer of Acetyl Groups into Mitochondria

    smpdb.ca/view/SMP0000466
    Metabolic

    Malate can also be used to create NADH by the conversion of malate to oxalacetic acid by malate dehydrogenase. … Malate dehydrogenase reduces oxalacetic acid to malate, which then is either transported back into the mitochondria by the malate-alpha ketoglutarate transporter or oxidized to pyruvate by malic enzyme

    Drugs: Pyruvic acid · Biotin · NADH · ATP · Citric acid
    Enzymes: Malate dehydrogenase, cytoplasmic, Mitochondrial 2-oxoglutarate/malate carrier protein
  7. Drug

    NADH

    go.drugbank.com/drugs/DB00157
    ApprovedNutraceutical

    NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved i...

  8. Indication

    Stress Incontinence (Female) (Male)

    go.drugbank.com/conditions/DBCOND0128715
    Drugs: Duloxetine
    Synonyms: Stress Incontinence (Female) (Male)
  9. Drug

    Fenproporex

    go.drugbank.com/drugs/DB01550
    ApprovedIllicitWithdrawn

    Fenproporex is an orally active stimulant drug, which was developed in the 1960s. It is used as an appetite suppressant and a treatment for obesity. It is listed as an illicit substance in many countries due to addiction issues and liste...

  10. Pathway

    Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease

    smpdb.ca/view/SMP0000374
    Disease

    Glycogen storage disease type 1A (GSD1A), or von Gierke disease, is caused by a defect in the G6PC gene which codes for Glucose-6-phosphatase. Glucose-6-phosphatase hydrolyzes glucose-6-phosphate to glucose and is responsible for the reg...

    Drugs: Pyruvic acid · Biotin · NADH · ATP · Magnesium cation · 2-phospho-D-glyceric acid +4 more
    Enzymes: Malate dehydrogenase, mitochondrial, Mitochondrial 2-oxoglutarate/malate carrier protein