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Displaying results 1201 - 1210 of 10000 in total
  1. Target

    Multidrug and toxin extrusion protein 2

    go.drugbank.com/bio_entities/BE0004752
    TransporterHumans

    Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney

    Polypeptides: Multidrug and toxin extrusion protein 2
  2. Target

    Nucleolar and coiled-body phosphoprotein 1

    go.drugbank.com/bio_entities/BE0005819
    TargetHumans

    It has intrinsic GTPase and ATPase activities (PubMed:9016786) … processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

    Polypeptides: Nucleolar and coiled-body phosphoprotein 1
  3. Target

    Cysteine and glycine-rich protein 1

    go.drugbank.com/bio_entities/BE0009098
    TargetHumans

    Could play a role in neuronal development

    Polypeptides: Cysteine and glycine-rich protein 1
  4. Target

    Sodium- and chloride-dependent taurine transporter

    go.drugbank.com/bio_entities/BE0009148
    TransporterHumans

    Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). … Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975)

    Polypeptides: Sodium- and chloride-dependent taurine transporter
  5. Target

    TRAF2 and NCK-interacting protein kinase

    go.drugbank.com/bio_entities/BE0009399
    TargetHumans

    MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed … Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.

    Polypeptides: TRAF2 and NCK-interacting protein kinase
  6. Drug

    Triptorelin

    go.drugbank.com/drugs/DB06825
    ApprovedInvestigationalVet approved

    After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. … Serum testosterone concentrations may fall to levels typically observed in surgically castrated men.

    Categories: Hormones and Related Agents, Amino Acids, Peptides, and ProteinsProducts: POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 3.75 mg/vial, POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 11.25 mg/vial
  7. Drug

    Lixisenatide

    go.drugbank.com/drugs/DB09265
    ApprovedInvestigational

    It is sold by Sanofi-Aventis under the brand name Adlyxin in the US[L763] and Lyxumia in the EU.[L764] Adlyxin recieved FDA approval July 28, 2016.[L763]

    Mixtures: LYXUMIA SOLUTION FOR INJECTION IN PRE-FILLED PEN 10MCG AND 20MCG (50mcg/mL and 100mcg/mL), LYXUMIA SOLUTION FOR INJECTION IN PRE-FILLED PEN 10MCG AND 20MCG (50mcg/mL and 100mcg/mL)Categories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and Proteins
  8. Drug

    Tropicamide

    go.drugbank.com/drugs/DB00809
    Approved

    Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors. … [A230103] Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures.

    Categories: Mydriatics and CycloplegicsProducts: Tropicamide 1% - Liq Oph 10mg/ml
  9. Drug

    Talazoparib

    go.drugbank.com/drugs/DB11760
    ApprovedInvestigational

    [L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and by the EMA in June 2019.[L47296] It was approved by Health Canada in September 2020. … Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair.

    Categories: Antineoplastic and Immunomodulating AgentsProducts: TALZENNA CAPSULE 1MG, Talzenna 1mg Hard Capsules
  10. Drug

    Dicloxacillin

    go.drugbank.com/drugs/DB00485
    ApprovedInvestigationalVet approved

    One of the penicillins which is resistant to penicillinase.

    Products: DICLOX SUSPENSION 250MG, DICLOXACILINA 250MG/5ML POLVO PARA RECONSTITUIR