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Displaying results 121 - 130 of 186 in total
  1. Target

    Zinc transporter ZIP2

    go.drugbank.com/bio_entities/BE0009889
    TransporterHumans

    The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential.

    Synonyms: Zrt- and Irt-like protein 2
  2. Target

    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

    go.drugbank.com/bio_entities/BE0000059
    TargetEnzymeHumans

    3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.

    Synonyms: 3-beta-HSD adrenal and gonadal type
  3. Target

    P-type Ca(2+) transporter

    go.drugbank.com/bio_entities/BE0009164
    TargetPlasmodium falciparum

    Synonyms: Sarcoplasmic and endoplasmic reticulum Ca-ATPase
  4. Target

    Zinc transporter ZIP6

    go.drugbank.com/bio_entities/BE0009887
    TransporterTargetHumans

    The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). … Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed

    Synonyms: Zrt- and Irt-like protein 6
  5. Target

    Thioredoxin reductase

    go.drugbank.com/bio_entities/BE0010144
    TargetMouse

    Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. … Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation.

    Synonyms: Thioredoxin and glutathione reductase
  6. Target

    Stabilin-1

    go.drugbank.com/bio_entities/BE0010944
    TargetHumans

    Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection.

    Synonyms: Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
  7. Target

    F-box/WD repeat-containing protein 1A

    go.drugbank.com/bio_entities/BE0021224
    TargetHumans

    Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). … Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435).

    Synonyms: F-box and WD repeats protein beta-TrCP
  8. Target

    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000377
    TargetHumans

    Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939 … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion

    Synonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  9. Target

    Cytohesin-2

    go.drugbank.com/bio_entities/BE0002654
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity).

    Synonyms: PH, SEC7 and coiled-coil domain-containing protein 2
  10. Target

    Excitatory amino acid transporter 3

    go.drugbank.com/bio_entities/BE0001054
    TargetTransporterHumans

    Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed

    Synonyms: Neuronal and epithelial glutamate transporter