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Clofedanol H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175053Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialChlorpromazine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175059Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialBenzquinamide H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175067Drug actionBenzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine re...
Enzymes: Nitric oxide synthase, endothelialAceprometazine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175068Drug actionAceprometazine is a is a drug with neuroleptic and anti-histamine properties. Although not widely prescribed, it is used in combination with meprobamate for the treatment of sleep disorders in France under the trade name Mepronizine. Ace...
Enzymes: Nitric oxide synthase, endothelialTripelennamine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174989Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialDexchlorpheniramine maleate H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175046Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialAripiprazole lauroxil H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175069Drug actionAripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of aripiprazole, which acts as a partial agonist at the D2 and 5-HT1A receptors, and ...
Enzymes: Nitric oxide synthase, endothelialGSK-1004723 H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175047Drug actionThe inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. … Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase.
Enzymes: Nitric oxide synthase, endothelialCaffeine Vasodilation Action Pathway
smpdb.ca/view/SMP0125283Drug actionThis calcium binds to calmodulin which activates Nitric oxide synthase. This catalyzes the reaction of L-Arginine into nitric oxide. … Nitric oxide then transports from the endothelial cells into the myocytes of the blood vessel located in the media.
Enzymes: Nitric oxide synthase, endothelialProlidase Deficiency (PD)
smpdb.ca/view/SMP0000207DiseaseProlidase deficiency is an autosomal recessive disorder. The enzyme prolidase cleaves iminodipeptides with N-terminal proline or hydroxyproline. Collagen has high levels of iminoacids therefore, these dipeptidases are important for colla...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: Nitric oxide synthase, brain