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A disintegrin and metalloproteinase with thrombospondin motifs 4
go.drugbank.com/bio_entities/BE0004687EnzymeTargetHumansMay play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease … Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391).
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4Potassium voltage-gated channel subfamily A member 2
go.drugbank.com/bio_entities/BE0004715TargetHumansPlays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity) … Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity).
Polypeptides: Potassium voltage-gated channel subfamily A member 2Potassium voltage-gated channel subfamily A member 3
go.drugbank.com/bio_entities/BE0004716TargetHumansAssuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with
Polypeptides: Potassium voltage-gated channel subfamily A member 3Potassium voltage-gated channel subfamily A member 5
go.drugbank.com/bio_entities/BE0004717TargetHumansMay play a role in regulating the secretion of insulin in normal pancreatic islets … Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.
Polypeptides: Potassium voltage-gated channel subfamily A member 5Potassium voltage-gated channel subfamily A member 6
go.drugbank.com/bio_entities/BE0004718TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. … The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:14575698, PubMed:2347305).
Polypeptides: Potassium voltage-gated channel subfamily A member 6Potassium voltage-gated channel subfamily A member 10
go.drugbank.com/bio_entities/BE0004720TargetHumansWhen opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane down their electrochemical gradient
Polypeptides: Potassium voltage-gated channel subfamily A member 10A disintegrin and metalloproteinase with thrombospondin motifs 13
go.drugbank.com/bio_entities/BE0009336EnzymeTargetHumansCleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13C-type lectin domain family 12 member A
go.drugbank.com/bio_entities/BE0010945TargetHumansActs as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation (PubMed:39143217). … Also acts as an inhibitor of dendritic cell maturation in an IL10-dependent manner (PubMed:16239426)
Polypeptides: C-type lectin domain family 12 member APhenol
go.drugbank.com/drugs/DB03255ApprovedInvestigationalPhenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. … Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization.
Mixtures: Kank-A with Blistex Medicated Lip, Phenol Saline InjCategories: Compounds used in a research, industrial, or household setting2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
go.drugbank.com/bio_entities/BE0000518TargetHumansPyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA
Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial