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Displaying results 1301 - 1310 of 10000 in total
  1. Pathway

    Metipranolol Action Pathway (New)

    smpdb.ca/view/SMP0126208
    Drug action

    Metipranolol is a beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors...

    Drugs: ATP · Metipranolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  2. Pathway

    Salbutamol Action Pathway

    smpdb.ca/view/SMP0126574
    Drug action

    The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. … Salbutamol is formulated as a racemic mixture of the R- and S-isomers.

    Drugs: ATP · Albuterol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  3. Pathway

    Nylidrin Action Pathway

    smpdb.ca/view/SMP0126575
    Drug action

    Nylidrin is a vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. It can be found under the brand name Arlidin. Nylidrin, also known as buphe...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Nylidrin
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  4. Pathway

    Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway

    smpdb.ca/view/SMP0126584
    Drug action

    Oxprenolol is a non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. Oxprenolol is a lipo...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Oxprenolol · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  5. Pathway

    Pindolol B2-Adrenergic Vasodilation Action Pathway

    smpdb.ca/view/SMP0126653
    Drug action

    Pindolol is a beta adrenoceptor antagonist and partial agonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. It can be found under the bran names Viskazide and Visken and is administered as an oral...

    Drugs: ATP · Pindolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  6. Pathway

    Acetaminophen Metabolism Pathway

    smpdb.ca/view/SMP0000640
    Drug metabolism

    Acetaminophen (APAP) is metabolized primarily in the liver. Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut. APAP can al...

    Drugs: Glutathione · NADH · ATP · Acetaminophen · Mesoheme · Uridine-5'-Diphosphate
    Enzymes: Glutathione S-transferase P, Glutathione S-transferase theta-1
  7. Pathway

    Ranitidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0122729
    Drug action

    Ranitidine is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epith...

    Drugs: ATP · Ranitidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  8. Pathway

    Cimetidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123152
    Drug action

    Cimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors. This ultimately reduces g...

    Drugs: ATP · Cimetidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Drug

    Mifamurtide

    go.drugbank.com/drugs/DB13615
    ApprovedInvestigational

    As a liposomal formulation, mifamurtide demonstrates an enhanced tumoricidal effect and improved safety profile [A31745]. Mifamurtide is marketed in Europe as Mepact for intravenous infusion. … In a large, randomized, open-label, multicenter, phase III trial, the treatment of mifamurtide in conjunction with three- or four-drug combination chemotherapy (doxorubicin, cisplatin, and high-dose methotrexate

    Products: MEPACT 4 MG INFÜZYONLUK DISPERSIYON KONSANTRESI IÇIN TOZ ,FLAKON, 1 ADET, MEPACT® POLVO PARA CONCENTRADO PARA DISPERSIÓN PARA PERFUSIÓN
  10. Drug

    Tezepelumab

    go.drugbank.com/drugs/DB15090
    ApprovedInvestigational

    [L39504] Tezepelumab was also approved by the European Commission on September 19, 2022.[L44712] … Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.

    Products: TEZSPIRE®, Tezspire 210 mg/1,91 ml Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem (1 adet)