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Displaying results 131 - 140 of 453 in total
  1. Target

    Folic acid synthesis protein FOL1

    go.drugbank.com/bio_entities/BE0004658
    TargetBaker's yeast

    Catalyzes three sequential steps of tetrahydrofolate biosynthesis.

    Polypeptides: Folic acid synthesis protein FOL1
  2. Target

    Free fatty acid receptor 2

    go.drugbank.com/bio_entities/BE0010131
    TargetHumans

    In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence … In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers.

    Polypeptides: Free fatty acid receptor 2
  3. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). … Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433).

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog
  4. Target

    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    go.drugbank.com/bio_entities/BE0003717
    TargetHumans

    Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). … Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299)

    Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  5. Target

    Cellular retinoic acid-binding protein 1

    go.drugbank.com/bio_entities/BE0000508
    CarrierTransporterTargetHumans

    Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors

    Polypeptides: Cellular retinoic acid-binding protein 1Synonyms: Cellular retinoic acid-binding protein I
  6. Target

    Proton-coupled amino acid transporter 1

    go.drugbank.com/bio_entities/BE0000536
    TargetTransporterHumans

    Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12527723, PubMed: … May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity).

    Polypeptides: Proton-coupled amino acid transporter 1Synonyms: Proton/amino acid transporter 1
  7. Target

    Retinoic acid receptor responder protein 1

    go.drugbank.com/bio_entities/BE0000653
    TargetHumans

    Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle

    Polypeptides: Retinoic acid receptor responder protein 1
  8. Target

    Cellular retinoic acid-binding protein 2

    go.drugbank.com/bio_entities/BE0000782
    CarrierTransporterHumans

    Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors

    Polypeptides: Cellular retinoic acid-binding protein 2Synonyms: Cellular retinoic acid-binding protein II
  9. Target

    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

    go.drugbank.com/bio_entities/BE0001832
    TargetHumans

    Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury (PubMed:16118205, PubMed:17402747). … Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747, PubMed:26616331).

    Polypeptides: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
  10. Target

    Gamma-aminobutyric acid receptor subunit theta

    go.drugbank.com/bio_entities/BE0003597
    TargetHumans

    GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217).

    Polypeptides: Gamma-aminobutyric acid receptor subunit theta