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Displaying results 131 - 140 of 259 in total
  1. Target

    Excitatory amino acid transporter 3

    go.drugbank.com/bio_entities/BE0001054
    TargetTransporterHumans

    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed … Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949).

    Synonyms: Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3
  2. Target

    Pendrin

    go.drugbank.com/bio_entities/BE0009874
    TransporterHumans

    Sodium-independent transporter of chloride and iodide (PubMed:10192399, PubMed:11932316, PubMed:12107249, PubMed:16684826, PubMed:24051746). … Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry (PubMed:10644529, PubMed:15155570, PubMed:24051746, PubMed:35601831).

    Synonyms: Sodium-independent chloride/iodide transporter
  3. Target

    Solute carrier family 13 member 1

    go.drugbank.com/bio_entities/BE0000022
    TransporterHumans

    Can also mediate the transport of selenate and thiosulfate (By similarity) … Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:11161786, PubMed:38552027, PubMed:39576865).

    Synonyms: Renal sodium/sulfate cotransporter
  4. Target

    Solute carrier family 13 member 2

    go.drugbank.com/bio_entities/BE0000447
    TransporterHumans

    Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small … intestine and renal proximal tubule (PubMed:10894787, PubMed:8967342, PubMed:9668069, PubMed:38552027).

    Synonyms: Renal sodium/dicarboxylate cotransporter
  5. Target

    Excitatory amino acid transporter 4

    go.drugbank.com/bio_entities/BE0002270
    TargetHumans

    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:26690923, PubMed:7791878). … Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:7791878).

    Synonyms: Sodium-dependent glutamate/aspartate transporter
  6. Target

    Organic cation/carnitine transporter 2

    go.drugbank.com/bio_entities/BE0000106
    TargetTransporterHumans

    Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. … Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine.

    Synonyms: High-affinity sodium-dependent carnitine cotransporter
  7. Target

    Acid-sensing ion channel 1

    go.drugbank.com/bio_entities/BE0000353
    TargetTransporterHumans

    Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and … Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899).

    Synonyms: Brain sodium channel 2Function: ligand-gated sodium channel activity
  8. Target

    Solute carrier family 12 member 3

    go.drugbank.com/bio_entities/BE0000419
    TargetTransporterHumans

    Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145 … Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity).

    Synonyms: Thiazide-sensitive sodium-chloride cotransporter
  9. Target

    Excitatory amino acid transporter 1

    go.drugbank.com/bio_entities/BE0001115
    TargetTransporterHumans

    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, … Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940).

    Synonyms: Sodium-dependent glutamate/aspartate transporter 1
  10. Target

    Linear primary-alkylsulfatase

    go.drugbank.com/bio_entities/BE0003744
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). … Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549).

    Synonyms: Sodium dodecyl sulfate hydrolase