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Displaying results 131 - 140 of 184 in total
  1. Target

    cDNA FLJ60754, moderately similar to Survival motor neuron protein

    go.drugbank.com/bio_entities/BE0009143
    TargetHumans

    Polypeptides: cDNA FLJ60754, moderately similar to Survival motor neuron proteinSynonyms: cDNA FLJ60754, moderately similar to Survival motor neuron protein
  2. Target

    Mitogen-activated protein kinase kinase kinase 20

    go.drugbank.com/bio_entities/BE0005595
    TargetHumans

    Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways … Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation

    Synonyms: Leucine zipper- and sterile alpha motif-containing kinase, Sterile alpha motif- and leucine zipper-containing kinase AZK
  3. Target

    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

    go.drugbank.com/bio_entities/BE0010396
    TargetHumans

    During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. … The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.

    Synonyms: Mitotic growth and transcription activator
  4. Target

    Glutamate decarboxylase

    go.drugbank.com/bio_entities/BE0010293
    TargetHumans

    Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.

    Synonyms: Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b
  5. Target

    Serine/threonine-protein kinase DCLK2

    go.drugbank.com/bio_entities/BE0009430
    TargetHumans

    Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. … May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity

    Synonyms: Doublecortin-like and CAM kinase-like 2
  6. Target

    Hepatitis A virus cellular receptor 2

    go.drugbank.com/bio_entities/BE0010551
    TargetHumans

    Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. … Expressed on natural killer (NK) cells and acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453).

    Synonyms: T-cell immunoglobulin and mucin domain-containing protein 3
  7. Target

    Tumor necrosis factor ligand superfamily member 13B

    go.drugbank.com/bio_entities/BE0000999
    TargetHumans

    Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. … Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

    Synonyms: TNF- and APOL-related leukocyte expressed ligand 1
  8. Target

    E3 ubiquitin-protein ligase CHIP

    go.drugbank.com/bio_entities/BE0021260
    TargetHumans

    -dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). … Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410

    Synonyms: STIP1 homology and U box-containing protein 1
  9. Target

    Excretory Secretory (ES) proteins

    go.drugbank.com/bio_entities/BE0009630
    TargetFasciola hepatica

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. … Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.

    Synonyms: Newly excysted juvenile proteins 5 and 7
  10. Target

    Serine/threonine-protein kinase TAO2

    go.drugbank.com/bio_entities/BE0004632
    TargetHumans

    Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. … This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation

    Synonyms: Thousand and one amino acid protein kinase 2