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Ivosidenib
go.drugbank.com/drugs/DB14568ApprovedInvestigationalThe drug is only effective in patients with a susceptible IDH1 mutation. … IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexAloe vera leaf
go.drugbank.com/drugs/DB13906ApprovedInvestigationalAloe vera, or _Aloe barbadensis miller_, is the most common species of Aloe that is cultivated for agricultural and medical purposes. … Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands.
Mixtures: Re-action E, Alcortin ASynonyms: Lu hui yeDexchlorpheniramine maleate
go.drugbank.com/drugs/DB09555ApprovedDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. … Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Mixtures: Re Drylex, Corzall PECategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsDexpanthenol
go.drugbank.com/drugs/DB09357ApprovedInvestigationalDexpanthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as [DB11204]. … Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium.
Mixtures: Tonicol Et A-D-C Ampoules/comprimes, The Fact Hair Care Scalp Booster AmpouleCategories: Vitamin B Complex, Vitamin D and AnaloguesEmpagliflozin
go.drugbank.com/drugs/DB09038ApprovedInvestigationalEmpagliflozin was further approved by the EMA in March 2022 and Health Canada in April 2022, making it the first and only approved treatment in Europe and Canada for adults with symptomatic chronic heart … Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney.
Mixtures: GLYXAMBI® 25 MG/ 5 MG, GLYXAMBI® 10 MG/ 5 MGCategories: P-glycoprotein substrates, Sodium-Glucose Transporter 2 InhibitorsEdaravone
go.drugbank.com/drugs/DB12243ApprovedInvestigational[L44017] Edaravone was initially granted orphan designation by the European Medicines Agency on June 19, 2015 [L44007] and was under regulatory review in Europe. … by the Committee for Medicinal Products for Human Use (CHMP) for a long-term study demonstrating the long-term efficacy and safety of edaravone.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 1-phenyl-3-methyl-5-oxo-2-pyrazoline, 3-methyl-1-phenyl-2-pyrazolin-5-oneNorgestrel Action Pathway
smpdb.ca/view/SMP0126522Drug actionNorgestrel is a synthetic progestin that has 2 stereoisomers, the active one is called levonorgestrel and the other one is dextronorgestrel. This drug is used in combination with ethinyl estradiol for oral contraception and prevention of...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Drospirenone Action Pathway
smpdb.ca/view/SMP0126538Drug actionDrospirenone is a synthetic progestin commonly found in popular oral contraceptives like Yaz, Angeliq, and Loryna. This drug is also indicated to control acne, menopause-associated symptoms, and premenstrual dysphoric disorder (PMDD) whe...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Dienogest Action Pathway
smpdb.ca/view/SMP0126541Drug actionDienogest is a semisynthetic progestogen derived from 19-nortestosterone and has antiandrogenic properties. This drug is used as a contraceptive or to treat endometriosis alone or combined with ethinylestradiol. Dienogest acts by binding...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Oxymetazoline
go.drugbank.com/drugs/DB00935ApprovedInvestigational[A215542] Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults. … Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α<sub>1</sub>- and α<sub>2</sub>-adrenoceptors.
Synonyms: 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol, 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolineInternational brands: Genasal Nasal Spray Up to 12 Hour Relief