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Pixantrone
go.drugbank.com/drugs/DB06193ApprovedWithdrawnAnother phase III trial, PIX-R, is now ongoing to clarify pixantrones place in therapy. It will compare pixantrone efficacy to that of gemcitabine. [2] … It also inhibits doxorubicinol formation in human myocardium. [3] As a result, it is believed to be less cardiotoxic while still exerting efficacy.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dioneMonoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0000533DiseaseMomoamine oxidase A (MAO-A) deficiency, or Brunner syndrome, is an X-linked recessive genetic disorder caused by a mutation in the MAOA gene that encodes for monoamine oxidase A. … With the inactivation of MAO-A, 3-methoxytyramine builds up as there are no reactions that use it, and both of these paths lead to a decrease in the concentration of homovanillic acid, as there are no
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Amine oxidase [flavin-containing] A, Amiloride-sensitive amine oxidase [copper-containing]Protein RecA
go.drugbank.com/bio_entities/BE0001257TargetDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA caus...
Synonyms: Recombinase AProtein RecA
go.drugbank.com/bio_entities/BE0003084TargetShigella flexneriCan catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA caus...
Synonyms: Recombinase AMonoamine oxidase
go.drugbank.com/bio_entities/BE0004909TargetEnzymeHumansCatalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amin...
Synonyms: MAO-A, Monoamine oxidase type APolypeptides: Amine oxidase [flavin-containing] ALeucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigationalLeucovorin, also known as folinic acid or citrovorum factor, is a reduced form of folic acid that serves as a vital coenzyme in nucleic acid synthesis. … [L56091, L56092] Historically developed in 1945, leucovorin has long been a staple on the World Health Organization’s List of Essential Medicines.
Mixtures: FERRITIN COMPLEXCategories: Vitamin B Complex, Compounds used in a research, industrial, or household settingSodium fluoride
go.drugbank.com/drugs/DB09325ApprovedInvestigationalSodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18]. … Now, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care.
Mixtures: Fluor-a-day, Fluor-a-dayCategories: Compounds used in a research, industrial, or household settingAlbendazole
go.drugbank.com/drugs/DB00518ApprovedInvestigationalVet approvedA benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Synonyms: O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate, 5-(propylthio)-2-carbomethoxyaminobenzimidazoleInternational brands: Ben-A, ALDe Novo Triacylglycerol Biosynthesis TG(a-21:0/a-15:0/a-13:0)
smpdb.ca/view/SMP0038283MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. … Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-17:0/a-17:0)
smpdb.ca/view/SMP0038314MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. … Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA.