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Magnesium Salicylate NSAID Action Pathway
smpdb.ca/view/SMP0124629Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because magnesium salicylate decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Drugs: Glutathione · Dinoprostone · Calcium · Magnesium salicylate · Mesoheme · Prostaglandin G2 +1 moreEnzymes: Prostaglandin E synthaseSalicylate-Sodium NSAID Action Pathway
smpdb.ca/view/SMP0124630Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because salicylate-sodium decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Enzymes: Prostaglandin E synthaseAntipyrine NSAID Action Pathway
smpdb.ca/view/SMP0124632Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because antipyrine decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Enzymes: Prostaglandin E synthaseBromfenac NSAID Action Pathway
smpdb.ca/view/SMP0126376Drug actionNon-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity. … In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased
Enzymes: Prostaglandin E synthasePhenylbutazone Action Pathway (New)
smpdb.ca/view/SMP0126545Drug actionDue to these two inactivations, the level of prostaglandins decreases and the inflammation is reduced in the surrounding tissues. Phenylbutazone is administered as an oral tablet.
Enzymes: Prostaglandin E synthaseTolfenamic acid Action Pathway
smpdb.ca/view/SMP0126549Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Tolfenamic acid is a nonsteroidal anti-inflammatory agent (NSAID) used to treat pain associated with the acute attack of migraine in adults.
Enzymes: Prostaglandin E synthaseMenthyl salicylate Action Pathway
smpdb.ca/view/SMP0126552Drug actionThe salicylate drugs target the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. … The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2.
Drugs: Glutathione · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 · Arachidonic Acid +1 moreEnzymes: Prostaglandin E synthaseEpithelial discoidin domain-containing receptor 1
go.drugbank.com/bio_entities/BE0001124TargetHumansAlso plays a role in tumor cell invasion. Phosphorylates PTPN11
Synonyms: TRK EBifonazole
go.drugbank.com/drugs/DB04794ApprovedBifonazole is an azole antifungal drug.
Synonyms: (+-)-1-(p,alpha-Diphenylbenzyl)imidazole, 1-(p,alpha-Diphenylbenzyl)imidazoleMixtures: CANESTEN ULTRA UÑAS 1%Calcium ascorbate
go.drugbank.com/drugs/DB14483ApprovedNutraceuticalMixtures: Vitamin A C E W.niacinam.beta Car.and Min., Vc IICategories: Compounds used in a research, industrial, or household setting, Vitamin C and analogues