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Tolmetin Action Pathway (New)
smpdb.ca/view/SMP0124606Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because tolmetin decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Enzymes: Prostaglandin E synthaseOxaprozin NSAID Action Pathway
smpdb.ca/view/SMP0124613Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Cytokines are produced in the central nervous system (CNS) during an inflammatory response.
Enzymes: Prostaglandin E synthaseEtodolac Action Pathway (New)
smpdb.ca/view/SMP0124626Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Cytokines are produced in the central nervous system (CNS) during an inflammatory response.
Enzymes: Prostaglandin E synthaseAcetylsalicylic Acid Action Pathway (New)
smpdb.ca/view/SMP0124628Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. … Because aspirin decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Drugs: Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Mesoheme · Prostaglandin G2 +1 moreEnzymes: Prostaglandin E synthaseDiclofenac NSAID Action Pathway
smpdb.ca/view/SMP0124633Drug actionProstaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Cytokines are produced in the central nervous system (CNS) during an inflammatory response.
Enzymes: Prostaglandin E synthaseNavepegritide
go.drugbank.com/drugs/DB17824ApprovedInvestigational[L56065] Navepegritide was approved by the US FDA in February 2026 for use in patients 2 years of age and older with achondroplasia with open epiphyses.[L56058,L56065] … Achondroplasia, the most prevalent skeletal dysplasia, is caused by a gain-of-function variant in the fibroblast growth factor receptor 3 (FGFR3), which leads to overactive downstream signaling that inhibits
Gadoxetic acid
go.drugbank.com/drugs/DB08884ApprovedInvestigationalGadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. … Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug.
Categories: Compounds used in a research, industrial, or household settingProducts: PRIMOVIST® SOLUCIÓN INYECTABLE, PRIMOVIST 0,25 MMOL/ML ENJEKSIYON ICIN COZELTI ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ADETRice bran
go.drugbank.com/drugs/DB14361ApprovedRice bran is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: Ari S-LinerRelacorilant
go.drugbank.com/drugs/DB14976ApprovedInvestigationalRelacorilant is a first-in-class, selective glucocorticoid receptor antagonist. … [L56089] Relacorilant was approved by the US FDA on March 25, 2026, for use in combination with [paclitaxel] in patients with certain platinum-resistant cancers.[L56093,L56089]
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2C8 InducersGlyburide
go.drugbank.com/drugs/DB01016ApprovedInvestigational[L8123] It is typically given to patients who cannot be managed with the standard first line therapy, [metformin]. … Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.
Mixtures: SIL-NORBORAL ® 5/500 MG, GLUCOVANCE® 500/5 MG. TABLETASCategories: Drugs Used in Diabetes, P-glycoprotein inhibitors