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Displaying results 141 - 150 of 208 in total
  1. Target

    Myelin basic protein

    go.drugbank.com/bio_entities/BE0010777
    TargetHumans

    may also be involved in signaling pathways in T-cells and neural cells. … They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis.

    Polypeptides: Myelin basic protein
  2. Target

    Cyclic nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0004922
    TargetHumans

    May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). … The catalytic site can adopt partially open conformations even in the inhibited state, contributing to the higher basal activity and rapid response kinetics characteristic of cones compared to rods (PubMed

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11A
  3. Target

    Serine/threonine-protein kinase TAO1

    go.drugbank.com/bio_entities/BE0009392
    TargetHumans

    Phosphorylates MAP2K3, MAP2K6 and MARK2. … Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases.

    Synonyms: Thousand and one amino acid protein kinase 1
  4. Target

    Holo-[acyl-carrier-protein] synthase

    go.drugbank.com/bio_entities/BE0001823
    TargetBacillus subtilis (strain 168)

    Also modifies the D-alanyl carrier protein but fails to recognize PCP and AcpK, an acyl carrier protein of secondary metabolism.

    Polypeptides: Holo-[acyl-carrier-protein] synthaseSynonyms: Holo-ACP synthase
  5. Target

    Holo-[acyl-carrier-protein] synthase

    go.drugbank.com/bio_entities/BE0002560
    TargetStreptococcus pneumoniae (strain ATCC BAA-255 / R6)

    Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

    Polypeptides: Holo-[acyl-carrier-protein] synthaseSynonyms: Holo-ACP synthase
  6. Target

    TIR domain-containing adapter molecule 1

    go.drugbank.com/bio_entities/BE0016552
    TargetHumans

    Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively … Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303,

    Synonyms: Proline-rich, vinculin and TIR domain-containing protein B
  7. Target

    E3 ubiquitin-protein ligase UHRF1

    go.drugbank.com/bio_entities/BE0018559
    TargetHumans

    Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 … Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (PubMed:24013172, PubMed:27595565).

    Synonyms: Ubiquitin-like PHD and RING finger domain-containing protein 1
  8. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed … Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213

    Synonyms: Rapamycin and FKBP12 target 1
  9. Target

    Serine/threonine-protein kinase TAO3

    go.drugbank.com/bio_entities/BE0009393
    TargetHumans

    Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). … Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521).

    Synonyms: Thousand and one amino acid protein 3
  10. Target

    Alpha-ketoglutarate-dependent dioxygenase FTO

    go.drugbank.com/bio_entities/BE0005795
    TargetHumans

    Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, … RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720

    Synonyms: Fat mass and obesity-associated protein