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Displaying results 1521 - 1530 of 6949 in total
  1. Target

    Nuclear receptor subfamily 1 group I member 2

    go.drugbank.com/bio_entities/BE0000956
    TargetHumans

    Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. … Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation.

    Polypeptides: Nuclear receptor subfamily 1 group I member 2Synonyms: Pregnane X receptor, Orphan nuclear receptor PAR1
  2. Target

    Gamma-aminobutyric acid type B receptor subunit 2

    go.drugbank.com/bio_entities/BE0002340
    TargetHumans

    Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating … Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 2, G protein-coupled receptor 51
  3. Target

    Nuclear receptor subfamily 1 group I member 3

    go.drugbank.com/bio_entities/BE0003848
    TargetHumans

    Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes.

    Polypeptides: Nuclear receptor subfamily 1 group I member 3Synonyms: Orphan nuclear receptor MB67, Constitutive androstane receptor
  4. Target

    Peroxisome proliferator-activated receptor gamma coactivator 1-beta

    go.drugbank.com/bio_entities/BE0009812
    TargetHumans

    Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids.

    Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-betaSynonyms: PGC-1-related estrogen receptor alpha coactivator
  5. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 2

    go.drugbank.com/bio_entities/BE0010561
    TargetHumans

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 2Synonyms: Leukocyte immunoglobulin-like receptor 2, Monocyte/macrophage immunoglobulin-like receptor 10
  6. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 1

    go.drugbank.com/bio_entities/BE0010562
    TargetHumans

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). … Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 1Synonyms: Leukocyte immunoglobulin-like receptor 1, Monocyte/macrophage immunoglobulin-like receptor 7
  7. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 4

    go.drugbank.com/bio_entities/BE0017129
    TargetHumans

    Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213). … Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462). Receptor for FN1 (PubMed:34089617).

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 4Synonyms: Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor 5
  8. Target

    Mas-related G protein-coupled receptor member X2

    go.drugbank.com/bio_entities/BE0018408
    TargetHumans

    Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109 … Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37

    Polypeptides: Mas-related G protein-coupled receptor member X2Function: C-C chemokine receptor activity
  9. Indication

    Triple-Negative Breast Cancer

    go.drugbank.com/conditions/DBCOND0068542
    Drugs: Atezolizumab
    Synonyms: Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 Negative
  10. Drug

    Drometrizole trisiloxane

    go.drugbank.com/drugs/DB11585
    Approved

    The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia … relatively few reports of adverse reactions, the FDA continues to cite that the existing scientific record is not sufficient to establish the compound as being generally recognized as safe and effective for

    Mixtures: Kiehls Activated Sun Protector Sunscreen SPF 50 For Face and Body For All Skin Types, Kiehls Activated Sun Protector Sunscreen SPF 30 For Face and Body For All Skin Types