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Doravirine
go.drugbank.com/drugs/DB12301ApprovedInvestigationaltreatments available for the management of HIV-1 infection. … [L4562] Doravirine is formally indicated for the treatment of HIV-1 infection in adult patients with no prior antiretroviral treatment experience, further expanding the possibility and choice of therapeutic
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseResorcinol
go.drugbank.com/drugs/DB11085ApprovedInvestigationalAlthough it is primarily indicated for use as a topical application, resorcinol also possesses a well-documented anti-thyroidal activity that is generally not relied upon for any kind of formal therapeutic
Categories: Anti-Acne Preparations for Topical UseButenafine
go.drugbank.com/drugs/DB01091ApprovedIn particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes.
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseTransient receptor potential cation channel subfamily A member 1
go.drugbank.com/bio_entities/BE0001122TargetHumansAlso acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312).
Polypeptides: Transient receptor potential cation channel subfamily A member 1Synonyms: Wasabi receptorTransient receptor potential cation channel subfamily M member 8
go.drugbank.com/bio_entities/BE0001186TargetHumansNon-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolal...
Polypeptides: Transient receptor potential cation channel subfamily M member 8Synonyms: Transient receptor potential p8, Long transient receptor potential channel 6Low affinity immunoglobulin gamma Fc region receptor III-A
go.drugbank.com/bio_entities/BE0002097TargetHumansReceptor for the invariable Fc fragment of immunoglobulin gamma (IgG). … The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor III-ASynonyms: IgG Fc receptor III-2, IgG Fc receptor III-ALow affinity immunoglobulin gamma Fc region receptor II-c
go.drugbank.com/bio_entities/BE0002100TargetHumansReceptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-cSynonyms: IgG Fc receptor II-cTransient receptor potential cation channel subfamily V member 3
go.drugbank.com/bio_entities/BE0003416TargetHumansNon-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures...
Polypeptides: Transient receptor potential cation channel subfamily V member 3Synonyms: Vanilloid receptor-like 3Transient receptor potential cation channel subfamily M member 7
go.drugbank.com/bio_entities/BE0004624TargetTransporterHumansBifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The...
Polypeptides: Transient receptor potential cation channel subfamily M member 7Synonyms: Long transient receptor potential channel 7Transient receptor potential cation channel subfamily V member 5
go.drugbank.com/bio_entities/BE0005112TransporterHumansConstitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubu...
Polypeptides: Transient receptor potential cation channel subfamily V member 5