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Aurora kinase B
go.drugbank.com/bio_entities/BE0003404TargetHumansOther known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histones H1.4 and H3 (PubMed:11756469, … The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (
Synonyms: Aurora- and IPL1-like midbody-associated protein 1Mitochondrial basic amino acids transporter
go.drugbank.com/bio_entities/BE0000097TargetHumansPlays a physiological role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (PubMed:19287344, PubMed:24652292) … Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:19287344, PubMed:24652292).
Polypeptides: Mitochondrial basic amino acids transporterAurora kinase A
go.drugbank.com/bio_entities/BE0000991TargetHumansRequired for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome
Synonyms: Ipl1- and aurora-related kinase 1E3 ubiquitin-protein ligase HUWE1
go.drugbank.com/bio_entities/BE0016469TargetHumansRegulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). … Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956).
Synonyms: HECT, UBA and WWE domain-containing protein 1NADPH oxidase
go.drugbank.com/bio_entities/BE0004904TargetHumansefficiency in chemokine uptake and degradation. … Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475).
Synonyms: SH3 and PX domain-containing protein 1A, SH3 and PX domain-containing protein 4Interferon alpha-2
go.drugbank.com/bio_entities/BE0003450TargetHumansProduced by macrophages, IFN-alpha have antiviral activities
Synonyms: LeIF AHepcidin
go.drugbank.com/bio_entities/BE0009858EnzymeTargetHumansActs by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, … Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored
Synonyms: LEAP-1Lymphoid enhancer-binding factor 1
go.drugbank.com/bio_entities/BE0009011TargetHumansTLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). … Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).
Synonyms: LEF-1Angiopoietin-2
go.drugbank.com/bio_entities/BE0010028TargetHumansBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).
Synonyms: ANG-2Angiopoietin-1
go.drugbank.com/bio_entities/BE0010681TargetHumansBinds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.
Synonyms: ANG-1