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Pyruvate kinase PKM
go.drugbank.com/bio_entities/BE0000088TargetHumansThe transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed
Synonyms: OIP-3Pyruvate Kinases
go.drugbank.com/bio_entities/BE0009686EnzymeTargetHumansThe transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis (PubMed:11960989).
Synonyms: OIP-3Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
go.drugbank.com/bio_entities/BE0000277TargetHumansMitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871 … Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton (PubMed:11566871).
Synonyms: CitrinAngiopoietin-2
go.drugbank.com/bio_entities/BE0010028TargetHumansBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).
Synonyms: ANG-2Angiopoietin-1
go.drugbank.com/bio_entities/BE0010681TargetHumansBinds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.
Synonyms: ANG-1Aminoglycoside nucleotidyltransferase (4')
go.drugbank.com/bio_entities/BE0003547EnzymeStaphylococcus aureusInactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
Synonyms: ANT(4')Angiopoietin-related protein 3
go.drugbank.com/bio_entities/BE0010034TargetHumansThe inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).
Synonyms: ANG-5Natriuretic peptides B
go.drugbank.com/bio_entities/BE0000979TargetHumansInvolved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed
Synonyms: Iso-ANPADP/ATP translocase 3
go.drugbank.com/bio_entities/BE0000624TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2, ANT 3Eph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansBinds to EFNA3, EFNA4 and EFNA5 … Generally has an overlapping and redundant function with EPHB2.
Synonyms: EPH- and ELK-related kinase