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Arylamine N-acetyltransferase 1
go.drugbank.com/bio_entities/BE0003608EnzymeHumansXenobiotic-metabolizing enzyme that catalyzes both N-acetylation (usually detoxification) and O-acetylation (usually bioactivation) of a wide range of species-specific substrates including hydrazines, … Plays a significant role in the bioactivation and detoxification of many drugs and carcinogens (Probable) (PubMed:9168895)
Synonyms: Aromatic-hydroxylamine O-acetyltransferase NAT1, N-hydroxyarylamine O-acetyltransferase NAT1NADH dehydrogenase
go.drugbank.com/bio_entities/BE0003040TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue...
Synonyms: H(2)O(2)-forming NADH oxidaseATP synthase peripheral stalk subunit OSCP, mitochondrial
go.drugbank.com/bio_entities/BE0009097TargetHumansPart of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity … These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256).
Synonyms: ATP synthase subunit ON-succinylamino acid racemase
go.drugbank.com/bio_entities/BE0002494TargetAmycolatopsis sp.Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). … Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).
Synonyms: o-succinylbenzoate synthase, o-succinylbenzoic acid synthase3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
go.drugbank.com/bio_entities/BE0000059TargetEnzymeHumans3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.
Synonyms: 3-beta-HSD adrenal and gonadal typeP-type Ca(2+) transporter
go.drugbank.com/bio_entities/BE0009164TargetPlasmodium falciparumSynonyms: Sarcoplasmic and endoplasmic reticulum Ca-ATPaseLysophosphatidylcholine acyltransferase 2
go.drugbank.com/bio_entities/BE0016122TargetEnzymeHumansAlso converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). … Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
Synonyms: 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-acylglycerophosphocholine O-acyltransferaseFunction: 1-acylglycerol-3-phosphate O-acyltransferase activityZinc transporter ZIP6
go.drugbank.com/bio_entities/BE0009887TransporterTargetHumansThe SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). … Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed
Synonyms: Zrt- and Irt-like protein 6Thioredoxin reductase
go.drugbank.com/bio_entities/BE0010144TargetMousePromotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. … Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation.
Synonyms: Thioredoxin and glutathione reductaseXylosyltransferase 1
go.drugbank.com/bio_entities/BE0016339EnzymeHumansCatalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. … Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity)
Synonyms: Peptide O-xylosyltransferase 1