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Aminoglycoside nucleotidyltransferase (4')
go.drugbank.com/bio_entities/BE0003547EnzymeStaphylococcus aureusInactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
Synonyms: ANT(4')Angiopoietin-related protein 3
go.drugbank.com/bio_entities/BE0010034TargetHumansThe inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).
Synonyms: ANG-5Natriuretic peptides B
go.drugbank.com/bio_entities/BE0000979TargetHumansInvolved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed
Synonyms: Iso-ANPADP/ATP translocase 3
go.drugbank.com/bio_entities/BE0000624TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2, ANT 3Eph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansBinds to EFNA3, EFNA4 and EFNA5 … Generally has an overlapping and redundant function with EPHB2.
Synonyms: EPH- and ELK-related kinaseAtrial natriuretic peptide receptor 1
go.drugbank.com/bio_entities/BE0000556TargetHumansand subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).
Synonyms: ANP-AAtrial natriuretic peptide receptor 2
go.drugbank.com/bio_entities/BE0000997TargetHumansReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
Synonyms: ANP-BAtrial natriuretic peptide receptor 3
go.drugbank.com/bio_entities/BE0002426TargetHumansMay function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. … Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production
Synonyms: ANP-CADP/ATP translocase 2
go.drugbank.com/bio_entities/BE0000709TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2ADP/ATP translocase 1
go.drugbank.com/bio_entities/BE0000599TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789).
Synonyms: ANT 1