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Droxidopa A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126494Drug actionDroxidopa is a medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Par...
Cinnarizine Calcium Channel Vasodilation Action Pathway
smpdb.ca/view/SMP0126667Drug actionCinnarizine is a drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (...
Chloropyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174913Drug actionChloropyramine is a first-generation H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allerg...
Fumarase Deficiency
smpdb.ca/view/SMP0000547DiseaseFumarase deficiency, also called fumaric aciduria, is a rare inborn error of metabolism (IEM) and autosomal recessive metabolic disorder caused by a defective mitochondrial fumarate hydratase. Fumarate hydratase catalyzes the conversion ...
Enzymes: Citrate synthase, mitochondrial2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000549Disease2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase ...
Enzymes: Citrate synthase, mitochondrialPyruvate Dehydrogenase Deficiency (E3)
smpdb.ca/view/SMP0000550DiseaseDihydrolipoamide dehydrogenase deficiency, which is also known as DLDD, DLD, E3 deficiency, pyruvate dehydrogenase E3 deficiency, DLD deficiency, E3-deficient maple syrup urine disease, is a rare inherited inborn error of metabolism. DLD...
Enzymes: Citrate synthase, mitochondrialJoubert Syndrome
smpdb.ca/view/SMP0000582DiseaseJoubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and an abnormal brain stem. The symptoms...
Gemcitabine Metabolism Pathway (old)
smpdb.ca/view/SMP0000603Drug metabolismGemcitabine is a cytidine analogue used in the treatment of certain cancers. Gemcitabine enters the cell via sodium nucleoside co-transporters (SLC29A1, SLC28A1, and SLC28A3), where it acts through multiple mechanisms to produce a cytoto...
Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway
smpdb.ca/view/SMP0125166Drug actionNorepinephrine is a sympathomimetic that is regularly found to be the primary neurotransmitter in postganglionic neurons. When taken pharmacologically it acts on the sympathetic nervous system in the heart and the blood vessels. It is ma...
Joubert Syndrome
smpdb.ca/view/SMP0125809DiseaseJoubert syndrome is a condition in which brain development is not completed as it should be, including the lack or underdevelopment of the part of the brain that regulates balance and coordination and an abnormal brain stem. The symptoms...