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Dolasetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126782Drug actionDolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The a...
Enzymes: Sodium-dependent serotonin transporterPipotiazine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126800Drug actionPipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic...
Enzymes: Sodium-dependent serotonin transporterOlanzapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126804Drug actionOlanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potent...
Enzymes: Sodium-dependent serotonin transporterOlanzapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126805Drug actionlanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potenti...
Enzymes: Sodium-dependent dopamine transporterMirtazapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126817Drug actionThe mechanism of action of mirtazapine, atypical antidepressant is not fully understood, but may be explained by its effects on central adrenergic and serotonergic activity. This drug exhibits a fast onset of action, a high level of resp...
Enzymes: Sodium-dependent serotonin transporterMinaprine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126818Drug actionMinaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree...
Enzymes: Sodium-dependent serotonin transporterCyproheptadine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126842Drug actionCyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors. Antagonism of serotonin on the appetite center of the hypothalamus may ...
Enzymes: Sodium-dependent serotonin transporterClozapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126963Drug actionClozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation...
Enzymes: Sodium-dependent dopamine transporterMaprotiline Action Pathway
smpdb.ca/view/SMP0126344Drug actionMaprotiline is an antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. This tetracyclic molecule strongly inhibits neuronal norepinephrine reuptake in the b...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Maprotiline +5 moreEnzymes: Sodium-dependent noradrenaline transporterMilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126429Drug actionMilnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used in the management of fibromyalgia, major depressive disorder, generalized anxiety disorder, chronic musculoskeletal pain and diabetic peripheral neuropat...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Sodium-dependent noradrenaline transporter