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Displaying results 1681 - 1690 of 2250 in total
  1. Target

    Proteasome subunit alpha type-5

    go.drugbank.com/bio_entities/BE0003914
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex zeta chain
  2. Target

    Proteasome subunit alpha

    go.drugbank.com/bio_entities/BE0003353
    TargetMycobacterium tuberculosis

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. … In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup).

    Synonyms: Proteasome core protein PrcA
  3. Target

    Proteasome subunit beta

    go.drugbank.com/bio_entities/BE0004188
    TargetMycobacterium tuberculosis

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. … In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup).

    Synonyms: Proteasome core protein PrcB
  4. Drug

    Megestrol

    go.drugbank.com/drugs/DB19378
    Approved

    Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  5. Target

    Phospholipid-transporting ATPase IF

    go.drugbank.com/bio_entities/BE0021215
    TargetHumans

    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from

    Synonyms: P4-ATPase flippase complex alpha subunit ATP11B
  6. Target

    Mediator of RNA polymerase II transcription subunit 1

    go.drugbank.com/bio_entities/BE0004382
    TargetHumans

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. … Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general

    Synonyms: Mediator complex subunit 1, Vitamin D receptor-interacting protein complex component DRIP205
  7. Drug

    Piretanide

    go.drugbank.com/drugs/DB02925
    Approved

    Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presenc...

    Categories: Genito Urinary System and Sex Hormones
  8. Drug

    Norgestrel

    go.drugbank.com/drugs/DB09389
    Approved

    Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only t...

    Synonyms: 17-ethynyl-17-hydroxy-18a-homoestr-4-en-3-oneCategories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System
  9. Target

    Syndecan-2

    go.drugbank.com/bio_entities/BE0002116
    TargetHumans

    Cell surface proteoglycan which regulates dendritic arbor morphogenesis

    Synonyms: Heparan sulfate proteoglycan core protein
  10. Drug

    Daclizumab

    go.drugbank.com/drugs/DB00111
    ApprovedInvestigationalWithdrawn

    The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. … Despite being approved for use, Zinbryta (daclizumab)'s complex pre-existing safety profile consisting of its restricted availability through a Risk Evaluation and Mitigation Strategy program [L1738] and